, Volume 61, Issue 1, pp 81–85 | Cite as

Cyclotron 99mTc Production and Quality Control for Medical Applications

  • A. H. Al RayyesEmail author
  • T. Assaad
  • Y. Ailouti


A new production method of 99mTc using a high-current solid target was tested. The separation and purification setup was developed to produce high quantity and high specific activity of 99mTcO 4 suitable for labeling various ligands for nuclear medicine imaging. A semiautomated target dissolution and separation system has been developed for 99mTcO 4 production. The separation is based on a chromatographic column system. The chemical and radiochemical purity was found to be in accordance with the US and European Pharmacopoeia specifications. 99% of activity in the final product belonged to 99mTc. Less than 1% of the 99mTc activity was not incorporated in the target product with MDP kits. Biodistribution data for the labeled MDP kits show that the quality of the produced 99mTc-pertechnetate is identical to that of the pertechnetate from 99Mo/99mTc generators. The application of 99mTc-ethylenedicysteine in human proves the good quality of the produced Na99mTcO4.


technetium-99m cyclotron radioisotope production ion-exchange chromatography solid targets 


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  1. 1.
    Arano, Y., Ann. Nucl. Med., 2002, vol. 16, no. 2, pp. 79–93. DOI: Scholar
  2. 2.
    Bandoli, G., Tisato, F., Dolmella, A., and Agostini, S., Coord. Chem. Rev., 2006, vol. 250, nos. 3–4, pp. 561–573. DOI: Scholar
  3. 3.
    Liu, S., Adv. Drug Deliv. Rev., 2008, vol. 60, no. 12, pp. 1347–1370. DOI: Scholar
  4. 4.
    Pillai, M.R., Dash, A., and Knapp, F.F., Jr., J. Nucl. Med., 2013, vol. 54, no. 2, pp. 313–323. DOI: Scholar
  5. 5.
    Ballinger, J.R., J. Label. Compd. Radiopharm., 2010, vol. 53, no. 4, pp. 167–168. DOI: Scholar
  6. 6.
    Von Hippel, F.N. and Kahn, L.H., Sci. Global Secur., 2006, vol. 14, nos. 2–3, pp. 151–162. DOI: Scholar
  7. 7.
    Scholten, B., Lambrecht, R.M., Cogneau, M., et al., Appl. Radiat. Isot., 1999, vol. 51, no. 1, pp. 69–80. DOI: Scholar
  8. 8.
    Takács, S., Szűcs, Z., Tárkányi, F., et al., J. Radioanal. Nucl. Chem., 2003, vol. 257, no. 1, pp. 195–201. DOI: Scholar
  9. 9.
    Lebeda, O. and Pruszynski, M., Appl. Radiat. Isot., 2010, vol. 68, no. 12, pp. 2355–2365. DOI: Scholar
  10. 10.
    Qaim, S.M., Sudára, S., Scholten, B., et al., Appl. Radiat. Isot., 2014, vol. 85, pp. 101–113. DOI: Scholar
  11. 11.
    Gagnon, K., Bénard, F., Kovacs, M., et al., Nucl. Med. Biol., 2011, vol. 38, no. 6, pp. 907–916. doi: Scholar
  12. 12.
    Al Rayyes, A.H. and Ailouti, Y., World J. Nucl. Sci. Technol., 2013, vol. 3, pp. 72–77. DOI: Scholar

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© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  1. 1.Cyclotron Division, Radioisotopes DepartmentAtomic Energy Commission of SyriaDamascusSyria

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