Cyclotron 99mTc Production and Quality Control for Medical Applications
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A new production method of 99mTc using a high-current solid target was tested. The separation and purification setup was developed to produce high quantity and high specific activity of 99mTcO 4 − suitable for labeling various ligands for nuclear medicine imaging. A semiautomated target dissolution and separation system has been developed for 99mTcO 4 − production. The separation is based on a chromatographic column system. The chemical and radiochemical purity was found to be in accordance with the US and European Pharmacopoeia specifications. 99% of activity in the final product belonged to 99mTc. Less than 1% of the 99mTc activity was not incorporated in the target product with MDP kits. Biodistribution data for the labeled MDP kits show that the quality of the produced 99mTc-pertechnetate is identical to that of the pertechnetate from 99Mo/99mTc generators. The application of 99mTc-ethylenedicysteine in human proves the good quality of the produced Na99mTcO4.
Keywordstechnetium-99m cyclotron radioisotope production ion-exchange chromatography solid targets
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