Connective tissue growth factor (CTGF) in the human dermis through ontogenesis
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Connective tissue growth factor (CTGF) was examined in the structures of dermis of humans with different ages, from 20 weeks of pregnancy to 85 years. By immunohistochemistry, the fibroblasts and blood vessels positively stained for CTGF were observed in the dermis of all examined ages. An age-dependent increase in the percent of the fibroblasts and blood vessels positively stained for CTGF in the dermis was observed. A statistically significant negative correlation was found between the age-dependent changes in the total number of fibroblasts, percent of the fibroblasts with positive staining for proliferating cell nuclear antigen, and portion of the fibroblasts with positive staining for CTGF. Another statistically significant negative correlation was found between the age-dependent changes in the number of blood vessels and portion of the blood vessels with a positive staining for CTGF. The results suggest that CTGF has an inhibitory influence on the angiogenesis and fibroblast renewal in the human dermis through ontogenesis.
Keywordsdermis ontogenesis fibroblasts blood vessels connective tissue growth factor
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- Hall-Glenn, F., De Young, R.A., Huang, B.L., et al., CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis, Adv. Geronotol., 2012, vol. 7, p. e30562.Google Scholar
- Kim, K.H., Park, G.T., Lim, Y.B., et al., Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway, Biochem. Biophys. Res. Commun., 2004, vol. 318, pp. 819–825.CrossRefPubMedGoogle Scholar
- Nishida, T., Kubota, S., Fukunaga, T., et al., CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes, Russ. J. Dev. Biol., 2003, vol. 196, pp. 265–275.Google Scholar
- Suzuma, K., Naruse, K., Suzuma, I., et al., Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells, J. Biol. Chem., 2000, vol. 275, pp. 40725–40731.CrossRefPubMedGoogle Scholar