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Russian Journal of Developmental Biology

, Volume 43, Issue 6, pp 319–331 | Cite as

Neonatal injections of pharmacological agents and their remote genotype-dependent effects in mice and rats

  • I. I. Poletaeva
  • O. V. Perepelkina
  • O. S. Boyarshinova
  • I. G. Lil’p
  • N. V. Markina
  • T. B. Timoshenko
  • A. V. Revishchin
Review

Abstract

Experimental data were reviewed which demonstrated that the neonatal injection effects of certain biologically active drugs (ACTH4–10 fragment and its analogue Semax, piracetam, caffeine, levetiracetam, busperone, etc.) could be detected in adult animals as changes in physiological and behavioral reactions and in several morphological traits as well. Audiogenic seizures proneness, anxiety-fear and exploration behavior as well as pain sensitivity were analyzed. The remote effects discovered were either similar in direction to those applied to an adult organism, or opposite to it. Pharmacological treatments of such type presumably interfere the CNS development during early postnatal ontogeny and change the normal pattern of brain development. These modulatory influences could be due to changes in neurotransmitter system development and are presumably capable to induce CNS morphological deviations (numbers of neurons, adult neurogenesis).

Keywords

ontogeny neonatal treatment genotype audiogenic epilepsy pain sensitivity anxiety exploration behavior mice rats 

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • I. I. Poletaeva
    • 1
  • O. V. Perepelkina
    • 1
  • O. S. Boyarshinova
    • 1
  • I. G. Lil’p
    • 1
  • N. V. Markina
    • 1
  • T. B. Timoshenko
    • 1
  • A. V. Revishchin
    • 2
  1. 1.Moscow State UniversityMoscowRussia
  2. 2.Institute for Gene BiologyRussian Academy of SciencesMoscowRussia

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