Russian Journal of Developmental Biology

, Volume 43, Issue 3, pp 181–184 | Cite as

Expression of transmitter receptor genes in early development of sea urchin Paracentrotus lividus

  • D. A. Nikishin
  • M. N. Semenova
  • Yu. B. Shmukler
Developmental Physiology


Neurotransmitters (including serotonin and acetylcholine) perform a number of prenervous functions in early sea urchin development. To detect the particular receptor components involved in these processes, we carried out a database search and nucleotide sequences homologous to serotonin receptor type 4, and the α6- and α10-subunits of nicotinic acetylcholine receptor were found among EST-clones from early Paracentrotus lividus embryos. Expression of these transcripts during early development was demonstrated using RT-PCR. These results are the first molecular biology evidence of serotonin and acetylcholine receptor expression in sea urchin early embryogenesis.


serotonin receptor nicotinic cholinoreceptor sea urchins early development 


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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • D. A. Nikishin
    • 1
  • M. N. Semenova
    • 1
  • Yu. B. Shmukler
    • 1
  1. 1.Koltsov Institute of Developmental BiologyRussian Academy of SciencesMoscowRussia

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