Survival of transgenic mouse embryos carrying different genetic constructs
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The survival of transgenic mouse embryos was studied as a function of the transgene structure. The data obtained indicate that the introduction of a chromosomal DNA fragment providing for the anchoring of interphase chromosomes on the nuclear envelope increases the efficiency of transgenesis in mice threefold due to their increased viability.
Key wordstransgenesis embryonic viability compartmentalization of genes in the nucleus
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