Russian Journal of Developmental Biology

, Volume 39, Issue 3, pp 168–171

Survival of transgenic mouse embryos carrying different genetic constructs

  • M. V. Glazkov
  • S. F. Drozd
  • P. K. Golovatenko-Abramov
  • M. Yu. Martynova
  • A. P. Nesterova
Developmental Genetics

Abstract

The survival of transgenic mouse embryos was studied as a function of the transgene structure. The data obtained indicate that the introduction of a chromosomal DNA fragment providing for the anchoring of interphase chromosomes on the nuclear envelope increases the efficiency of transgenesis in mice threefold due to their increased viability.

Key words

transgenesis embryonic viability compartmentalization of genes in the nucleus 

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • M. V. Glazkov
    • 1
  • S. F. Drozd
    • 1
  • P. K. Golovatenko-Abramov
    • 2
  • M. Yu. Martynova
    • 2
  • A. P. Nesterova
    • 2
  1. 1.Kol’tsov Institute of Developmental BiologyRussian Academy of SciencesMoscowRussia
  2. 2.Vavilov Institute of General GeneticsRussian Academy of SciencesMoscowRussia

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