Biology Bulletin

, Volume 46, Issue 6, pp 577–582 | Cite as

Effects of Limonium effusum Ethanol Extracts on Cell Proliferation and Mutagenicity

  • Yasin ErenEmail author

AbstractLimonium plants have commonly used as antibacterial, styptical, anti-swelling agent, digestive system regulator, anticarcinogenic, and antiviral in alternative medicine. Beside this, different extracts of Limonium plants have mutagenic, cytotoxic and genotoxic effects. Different parts of Limonium effusum (Boiss.) Kuntze ethanol extracts were used to determine the mutagenic and cytotoxic effects. Ames test was carried out with Salmonella typhimurium TA98, and TA100 strains to determine the mutagenicity. Ames test results showed that root 1000 μg/plate of plant has mutagenic effect and root extracts have weak mutagenicity with TA98 strain. MTT test was carried out with MDBK (Madin-Darby Bovine Kidney) cells to determine the cytotoxicity. Cytotoxicity results showed that root 50, 25, 12.5 and 6.25 μg/mL extracts were increased the proliferation rates in 24 h treatment. All doses of root extracts decreased the rates in 96 h. All concentrations of stem decreased the proliferation rates in 96 h. Leaf extracts increased the rates in 24 h but decreased in 48, 72, and 96 h.

Keywords: Limonium effusum, MTT test Ames test mutagenicity cytotoxicity 



The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.


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© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  1. 1.Department of Science Education, Faculty of Education, Süleyman Demirel UniversityIspartaTurkey

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