The Effect of Confounding Factors in Biomodeling of Intoxication
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The results of modeling intoxication in rats using lead acetate against the background of metabolic changes in the body and prenatal stress are presented. The motor activity and cognitive abilities, serum total cholesterol and lipid fractions, and bioelectric activity of the brain have been identified by testing the animals. It was found that intoxication with lead acetate against hyperglycemia or hyperlipidemia compared with the individual effects of lead acetate resulted in impaired cognitive abilities of animals and pronounced atherogenic changes, which included an increase in the concentrations of low-density lipoprotein cholesterol, triglycerides, and an atherogenic coefficient. It was recorded that lead intoxication complicated by metabolic disorders caused more prominent pathological changes in ECG parameters, such as tachycardia and a change in the duration of intraventricular conduction.
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Conflict of interests. The authors declare that they have no conflict of interest.
Statement on the welfare of animals. All experiments were conducted in accordance with the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes (Strasburg, 1986) and Good Laboratory Practice (order of the Ministry of Health and Social Development of the Russian Federation no. 708n, August 23, 2010). Experiments were approved by a Local Ethical Committee (protocol no. 5, November 14, 2012).
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