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Biology Bulletin

, Volume 46, Issue 3, pp 277–283 | Cite as

EPR Spectrometric Estimation of the Distribution of Intravenously Injected Nanodiamonds in Mice

  • E. V. InzhevatkinEmail author
  • A. V. Baron
  • N. G. Maksimov
  • M. B. Volkova
  • A. P. Puzyr
  • V. S. Bondar
HUMAN AND ANIMAL PHYSIOLOGY
  • 30 Downloads

Abstract

The distribution in mice of intravenously injected modified nanodiamonds (MNDs) obtained by detonation synthesis was studied using electron paramagnetic resonance (EPR) spectrometry. It has been shown that 2.5 h after MND injection into the tail vein of mice, the nanoparticles accumulate mainly in the lungs and liver of animals; much smaller amounts of nanoparticles were found in the kidneys and heart. The presence of MNDs in the samples of blood, spleen, brain, and thigh muscles of mice was not detected within the sensitivity of the method used.

Notes

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Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  • E. V. Inzhevatkin
    • 1
    Email author
  • A. V. Baron
    • 2
    • 3
  • N. G. Maksimov
    • 4
  • M. B. Volkova
    • 1
    • 3
  • A. P. Puzyr
    • 2
  • V. S. Bondar
    • 2
  1. 1.International Scientific Center for Studies of Extreme States of Organisms, Federal Research Center Krasnoyarsk Science Center, Siberian Branch, Russian Academy of SciencesKrasnoyarskRussia
  2. 2.Institute of Biophysics, Federal Research Center Krasnoyarsk Science Center, Siberian Branch, Russian Academy of SciencesKrasnoyarskRussia
  3. 3.Siberian Federal UniversityKrasnoyarskRussia
  4. 4.Institute of Chemistry and Chemical Technology, Federal Research Center Krasnoyarsk Science Center, Siberian Branch, Russian Academy of SciencesKrasnoyarskRussia

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