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Biology Bulletin

, Volume 45, Issue 4, pp 394–399 | Cite as

The Protective Effect of Semax in a Model of Stress-Induced Impairment of Memory and Behavior in White Rats

  • N. Yu. Glazova
  • E. A. Sebentsova
  • D. M. Manchenko
  • L. A. Andreeva
  • L. V. Dergunova
  • N. G. Levitskaya
  • S. A. Limborska
  • N. F. Myasoedov
Animal and Human Physiology
  • 5 Downloads

Abstract

The effect of acute restrained stress on cognitive functions and anxiety-like behavior in white rats has been studied; furthermore, the influence of the fragment ACTH(4–10) analog Semax on the stress effects was evaluated. It was shown that stress exposure leads to impaired retention of previously acquired food-motivated maze task as well as reduced anxiety-like behavior in the elevated plus maze in rats. Preliminary intraperitonial administration of Semax (0.1 mg/kg) attenuates cognitive impairment caused by acute restrained stress, but it does not affect stress-induced changes in anxiety.

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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • N. Yu. Glazova
    • 1
  • E. A. Sebentsova
    • 1
  • D. M. Manchenko
    • 2
  • L. A. Andreeva
    • 1
  • L. V. Dergunova
    • 1
  • N. G. Levitskaya
    • 1
    • 2
  • S. A. Limborska
    • 1
  • N. F. Myasoedov
    • 1
  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia
  2. 2.Faculty of BiologyMoscow State UniversityMoscowRussia

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