Advertisement

Biology Bulletin

, Volume 33, Issue 5, pp 437–440 | Cite as

Biological functions of allantoin

  • A. V. Shestopalov
  • T. P. Shkurat
  • Z. I. Mikashinovich
  • I. O. Kryzhanovskaya
  • M. A. Bogacheva
  • S. V. Lomteva
  • V. N. Prokof’ev
  • E. P. Gus’kov
Biochemistry

Abstract

A historical review of allantoin research is presented. An increased allantoin level in the trophoblast and serum of pregnant women has been demonstrated. Allantoin concentration decreased in placental tissues and increased in the serum in developing placental insufficiency.

Keywords

Uric Acid Biology Bulletin Placental Tissue Pregnancy Term Allantoin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Benzie, I.F., Chung, W., and Tomlinson, B., Simultaneous Measurement of Allantoin and Urate in Plasma: Analytical Evaluation and Potential Clinical Application in Oxidant: Antioxidant Balance Studies, Clin. Chem., 1999, vol. 45, pp. 901–904.PubMedGoogle Scholar
  2. Burlev, V.A., Free Radical Oxidation in the Mother-Placenta-Fetus System in Obstetrical Pathology, Extended Abstract of Doctoral (Med.) Dissertation, Moscow: GU Nauchn. tsentr akusherstva, ginekologii i perinatologii, Russian Academy of Medical Sciences, 1992.Google Scholar
  3. Chen, X.B. and Gomes, M.J., Estimation of Microbial Protein Supply Cattle Based on Urinary Excretion of Purine Derivates—An Overview of the Technical Details, Bucksburn: Occasional Publication, 1992.Google Scholar
  4. Folin, O., Bergland, H., and Derick, C., The Uric Acid Problem, J. Biol. Chem., 1924, vol. LX, no. 2, pp. 361–471.Google Scholar
  5. Gus’kov, E.P. and Shkurat, T.P., Genome Instability in Human Somatic Cells As an Adaptive Norm, Usp. Sovrem. Biol., 1989, vol. 108, no. 2(5), pp. 163–171.Google Scholar
  6. Gus’kov, E.P., Shkurat, T.P., Milyutina, N.P., et al., Effect of Allantoin on the Activity of Enzymes Providing Regulation of the ROS-Dependent Status of an Organism, Dokl. Akad. Nauk, 2001, vol. 379, no. 3, pp. 398–401.Google Scholar
  7. Gus’kov, E.P., Kletskii, M.E., Kornienko, I.V., et al., Allantoin as Free-Radical Scavenger, Dokl. Akad. Nauk, 2002, vol. 383, no. 3, pp. 105–107.Google Scholar
  8. Guskov, E.P., Shkurat, T.P., Shimanskaja, E.I., and Guskova, S.I., Genetic Effects of Hyperbaric Oxygen Therapy, Mutation Res., 1990, vol. 241, no. 1, pp. 341–347.PubMedGoogle Scholar
  9. Hellsten, Y., Svensson, M., Sjodin, B., et al., Allantoin Formation and Urate and Glutathione Exchange in Human Muscle during Submaximal Exercise, Free Radic. Biol. Med, 2001, vol. 31, pp. 1313–1322.PubMedCrossRefGoogle Scholar
  10. Iris, F., Benzie, I., Chung, W., and Tomlinson, B., Simultaneous Measurement of Allantoin and Urate in Plasma: Analytical Evaluation and Potential Clinical Application in Oxidant: Antioxidant Balance Studies, Clin. Chem., 1999, vol. 45, pp. 901–904.Google Scholar
  11. Keniya, M.V., Lukash, A.I., and Gus’kov, E.P., The Role of Low Molecular Weight Antioxidants in Oxidative Stress, Usp. Sovrem. Biol., 1993, vol. 113, no. 4, pp. 456–470.Google Scholar
  12. Kock, R., Delvoux, B., Sigmund, M., and Grelling, H., A Comparative Study of the Concentrations of Hypoxanthine, Xanthine, Uric Acid and Allantoin in the Peripheral Blood of Normals and Patients with Acute Myocardial Infarction and Other Ischaemic Diseases, Eur J. Clin. Chem. Clin. Biochem., 1994, vol. 32, pp. 837–842.PubMedGoogle Scholar
  13. Kolesnikova, L.I., The Role of Lipid Peroxidation Processes in Complications of Abnormal Pregnancy, Extended Abstract of Doctoral (Med.) Dissertation, Irkutsk: Nauch. tsentr med. ekologii VSNTs SO RAMN, 1993.Google Scholar
  14. Komar, A.A., Melki, R., and Cullin, C., The [Ure3] Yeast Prion: From Genetics to Biochemistry, Biochemistry, 1999, vol. 64, no. 12, pp. 1401–1407.PubMedGoogle Scholar
  15. Lagendijk, J., Ubbink, J.B., and Vermaak, W.J., The Determination of Allantoin, A Possible Indicator of Oxidant Status, in Human Plasma, J. Chromatogr. Sci., 1995, vol. 33, pp. 186–193.PubMedGoogle Scholar
  16. Ma, S.W., Tomlinson, B., and Benzie, I.F., A Study of the Effect of Oral Glucose Loading on Plasma Oxidant: Antioxidant Balance in Normal Subjects, Eur. J. Nutr., 2005, vol. 44, pp. 250–254.PubMedCrossRefGoogle Scholar
  17. Marklund, N., Ostman, B., Nalmo, L., et al., Hypoxanthine, Uric Acid and Allantoin As Indicators of in Vivo Free Radical Reactions. Description of a HPLC Method and Human Brain Microdialysis Data, Acta. Neurochir., 2000, vol. 142, pp. 1135–1141.CrossRefGoogle Scholar
  18. Mikami, T., Kita, K., Tomita, S., et al., Is Allantoin in Serum and Urine a Useful Indicator of Exercise-Induced Oxidative Stress in Humans?, Free Radic. Res., 2000, vol. 32, pp. 235–244.PubMedGoogle Scholar
  19. Mutlu-Turkoglu, U., Ademoglu, E., Ibrahimoglu, L., et al., Imbalance between Lipid Peroxidation and Antioxidant Status in Preeclampsia, Gynecol. Obstet. Invest., 1998, vol. 46, no. 1, pp. 37–40.PubMedCrossRefGoogle Scholar
  20. Poranen, A.K., Aubry, J., Kujari, H., and Ekblad, U., Expression of Nitric Oxide Synthase in Normal and Preeclamptic Placental Tissue and Effects of Glyceryl Trinitrate and Shear Stress on Placental Blood Flow, Acta Obstet. Gynecol. Scand., 1998, vol. 77, no. 6, pp. 594–597.PubMedCrossRefGoogle Scholar
  21. Rasanen, L.A., Myllymaki, T., Hyyppa, S., et al., Accumulation of Allantoin and Uric Acid in Plasma of Exercising Trotters, Am. J. Vet. Res., 1993, vol. 54, pp. 1923–1928.PubMedGoogle Scholar
  22. Sallum, A., Shestopalov, A.V., Mikashinovich, Z.I., and Kryzhanovskaya, I.O., Dynamics of Products of Purine Metabolism in Placenta, Izv. Sev.-Kavk. Nauchn. Tsentra Vyssh. Shk., Estestv. Nauki, 2004, pp. 63–67.Google Scholar
  23. Shestakov, V.A., Boichevskaya, N.O., and Sherstnev, M.P., Chemiluminescence of Blood Plasma in the Presence of Hydrogen Peroxide, Vopr. Med. Khim., 1979, vol. 25, no. 2, pp. 132–137.PubMedGoogle Scholar
  24. Uyeno, D., The Physical Properties and Chemical Composition of Human Amniotic Fluid, J. Biol. Chem., 1917, vol. 37, no. 1, pp. 77–103.Google Scholar
  25. Walker, J.J., Antioxidants and Inflammatory Cell Response in Preeclampsia, Sem. Reprod. Endocrinol., 1998, vol. 16, no. 1, pp. 47–55.CrossRefGoogle Scholar
  26. Wang, Y. and Walsh, S.W., Antioxidant Activities and mRNA Expression of Superoxide Dismutase, Catalase, and Glutathione Peroxidase in Normal and Preeclamptic Placentas, J. Soc. Gynecol. Invest., 1996, vol. 3, pp. 174–184.CrossRefGoogle Scholar
  27. Wulf, D., Free Radicals in the Physiological. Control of Cell Function, Physiol. Rev., 2002, vol. 82, pp. 47–95.Google Scholar
  28. Yardim-Akaydin, S., Sepici, A., Ozkan, Y., et al., Oxidation of Uric Acid in Rheumatoid Arthritis: Is Allantoin a Marker of Oxidative Stress?, Free Radic. Res., 2004, vol. 38, no. 6, pp. 623–628.PubMedCrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  • A. V. Shestopalov
    • 2
  • T. P. Shkurat
    • 1
  • Z. I. Mikashinovich
    • 2
  • I. O. Kryzhanovskaya
    • 2
  • M. A. Bogacheva
    • 1
  • S. V. Lomteva
    • 1
  • V. N. Prokof’ev
    • 1
  • E. P. Gus’kov
    • 1
  1. 1.Research Institute of BiologyRostov State UniversityRostov-on-DonRussia
  2. 2.Rostov State Medical UniversityRostov-on-DonRussia

Personalised recommendations