Journal of Analytical Chemistry

, Volume 74, Issue 11, pp 1096–1103 | Cite as

Surfactant-Assisted Voltammetric Determination of Olanzapine at Amine Functionalized TiO2/Multi-Walled Carbon Nanotubes Nanocomposite

  • Majid ArvandEmail author
  • Akram Pourhabib


This paper describes the development and utilization of a new nanocomposite consisting of amine-functionalized TiO2/multi-walled carbon nanotubes and sodium dodecylsulfate for glassy carbon electrode modification. The nanocomposite was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy and scanning electron microscopy. The modified electrode was used for electrochemical characterization of olanzapine (OLZ). The efficiency of modified electrode for electrocatalytic oxidation of OLZ was studied by cyclic voltammetry and square wave voltammetry in phosphate buffer solution (pH 7.0). Using square wave voltammetry, the prepared sensor showed good sensitivity and selectivity with low overpotential for the determination of OLZ in the ranges from 0.05 to 0.1 and 0.1 to 10 μM, with a detection limit of 8 nM. The proposed method was employed for the determination of OLZ in tablet and blood serum samples without any pretreatment steps.


nanocomposite amine-functionalized TiO2 surfactant olanzapine 



The authors are thankful to the post-graduate office of Guilan University for the support of this work.


The authors declare no conflict of interest.


  1. 1.
    Wang, J., Analytical Electrochemistry, Hoboken, NJ: Wiley, 2006, 3rd ed.CrossRefGoogle Scholar
  2. 2.
    Vittal, R., Gomathi, H., and Kim, K.J., Adv. Colloid Interface, 2006, vol. 119, p. 55.CrossRefGoogle Scholar
  3. 3.
    Li, C., Bioelectrochemistry, 2007, vol. 70, p. 263.PubMedCrossRefGoogle Scholar
  4. 4.
    Blanco-López, M.C., Lobo-Castañón, M.J., Miranda-Ordieres, A.J., and Tuñón-Blanco, P., Electroanalysis, 2007, vol. 19, p. 207.CrossRefGoogle Scholar
  5. 5.
    Jain, R., Dwivedi, A., and Mishra, R., Langmuir, 2009, vol. 25, p. 10 364.CrossRefGoogle Scholar
  6. 6.
    Levent, A., Yardim, Y., and Senturk, Z., Electrochim. Acta, 2009, vol. 55, p. 190.CrossRefGoogle Scholar
  7. 7.
    de Araújo, T.A., Marcos Jacques Barbosa, A., Viana, L.H., and Sousa Ferreira, V., Colloids Surf., B, 2010, vol. 79, p. 409.CrossRefGoogle Scholar
  8. 8.
    Jain, R., Yadav, R.K., and Rather, J.A., Colloids Surf., A, 2010, vol. 366, p. 63.CrossRefGoogle Scholar
  9. 9.
    Yi, H. and Li, C., Russ. J. Electrochem., 2007, vol. 43, p. 1377.CrossRefGoogle Scholar
  10. 10.
    Zhao, Q., Gan, Z., and Zhuang, Q., Electroanalysis, 2002, vol. 14, p. 1609.CrossRefGoogle Scholar
  11. 11.
    Wang, J., Electroanalysis, 2005, vol. 17, p. 7.CrossRefGoogle Scholar
  12. 12.
    Gooding, J.J., Wibowo, R., Liu, J.Q., Yang, W., Losic, D., Orbons, S., Mearns, F.J., Shapter, J.G., and Hibbert, D.B., J. Am. Chem. Soc., 2003, vol. 125, p. 9006.PubMedCrossRefGoogle Scholar
  13. 13.
    Yu, X., Chattopadhyay, D., Galeska, I., Papadimitrakopoulos, F., and Rusling, J.F., Electrochem. Commun., 2003, vol. 5, p. 408.CrossRefGoogle Scholar
  14. 14.
    Fei, S., Chen, J., Yao, S., Deng, G., He, D., and Kuang, Y., Anal. Biochem., 2005, vol. 39, p. 29.CrossRefGoogle Scholar
  15. 15.
    Jacobs, C.B., Peairs, M.J., and Venton, B.J., Anal. Chim. Acta, 2010, vol. 662, p. 105.PubMedCrossRefGoogle Scholar
  16. 16.
    Xiao, F., Zhao, F., Li, J., Yan, R., Yu, J., and Zeng, B., Anal. Chim. Acta, 2007, vol. 596, p. 79.PubMedCrossRefGoogle Scholar
  17. 17.
    Guo, M., Chen, J., Li, J., Tao, B., and Yao, S., Anal. Chim. Acta, 2005, vol. 532, p. 71.CrossRefGoogle Scholar
  18. 18.
    Musameh, M., Wang, J., Merkoçi, A., and Lin, Y., Electrochem. Commun., 2002, vol. 4, p. 743.CrossRefGoogle Scholar
  19. 19.
    Qureshi, A., Kang, W.P., Davidson, J.L., and Gurbuz, Y., Diamond Relat. Mater., 2009, vol. 18, p. 1401.CrossRefGoogle Scholar
  20. 20.
    Yang, Z., Choi, D., Kerisit, S., Rosso, K.M., Wang, D., Zhang, J., Graff, G., and Liu, J., J. Power Sources, 2009, vol. 192, p. 588.CrossRefGoogle Scholar
  21. 21.
    Shi, M., Shen, J., Ma, H., Li, Z., Lu, X., Li, N., and Ye, M., Colloids Surf., A, 2012, vol. 405, p. 30.CrossRefGoogle Scholar
  22. 22.
    Ma, F., Shi, T., Gao, J., Chen, L., Guo, W., Guo, Y., and Wang, S., Colloids Surf., A, 2012, vol. 401, p. 116.CrossRefGoogle Scholar
  23. 23.
    Liu, G., Jian, W., Jin, H., Shi, Z., and Qiao, G., Mater. Lett., 2011, vol. 65, p. 3468.CrossRefGoogle Scholar
  24. 24.
    Kolodiazhnyi, T., Annino, G., Spreitzer, M., Taniguchi, T., Freer, R., Azough, F., Panariello, A., and Fitzpatrick, W., Acta Mater., 2009, vol. 57, p. 3402.CrossRefGoogle Scholar
  25. 25.
    Li, Y., Hagen, J., Schaffrath, W., Otschik, P., and Haarer, D., Sol. Energy Mater. Sol. Cells, 1999, vol. 56, p. 167.CrossRefGoogle Scholar
  26. 26.
    Macwan, D.P., Dave, P.N., and Chaturvedi, S., J. Mater. Sci., 2011, vol. 46, p. 3669.CrossRefGoogle Scholar
  27. 27.
    Boccaccini, A.R. and Zhitomirsky, I., Curr. Opin. Solid State Mater. Sci., 2002, vol. 6, p. 251.CrossRefGoogle Scholar
  28. 28.
    Shi, L., Shan, J., Ju, Y., Aikens, P., and Prud’homme, R.K., Colloids Surf., A, 2012, vol. 396, p. 122.CrossRefGoogle Scholar
  29. 29.
    Sampaio, M.J., Silva, C.G., Marques, R.R.N., Silva, A.M.T., and Faria, J.L., Catal. Today, 2011, vol. 161, p. 91.CrossRefGoogle Scholar
  30. 30.
    Liu, H., Ma, H., Zhou, W., Liu, W., Jie, Z., and Li, X., Appl. Surf. Sci., 2012, vol. 258, p. 1991.CrossRefGoogle Scholar
  31. 31.
    Beasley, C.M., Jr., Tollefson, G., Tran, P., Satterlee, W., Sanger, T., and Hamilton, S., Neuropsychopharmacology, 1996, vol. 14, p. 111.PubMedCrossRefGoogle Scholar
  32. 32.
    Gerlach, J. and Peacock, L., Int. Clin. Psychopharmacol., 1995, vol. 10, p. 39.PubMedGoogle Scholar
  33. 33.
    Arvand, M. and Palizkar, B., Mater. Sci. Eng., C, 2013, vol. 33, p. 4876.CrossRefGoogle Scholar
  34. 34.
    Rusling, J.F. and Nassar, A.F., J. Am. Chem. Soc., 1993, vol. 115, p. 11 891.CrossRefGoogle Scholar
  35. 35.
    Jain, R., Radhapyari, K., and Jadon, N., J. Electrochem. Soc., 2008, vol. 155, p. 104. CrossRefGoogle Scholar
  36. 36.
    Jain, R., Mishra, R., and Dwivedi, A., Colloids Surf., A, 2009, vol. 337, p. 74.CrossRefGoogle Scholar
  37. 37.
    Jain, R., Dwivedi, A., and Mishra, R., J. Colloid Interface Sci., 2008, vol. 318, p. 296.PubMedCrossRefGoogle Scholar
  38. 38.
    Reis, A.P., Tarley, C.R.T., Maniasso, N., and Kubota, L.T., Talanta, 2005, vol. 67, p. 829.PubMedCrossRefGoogle Scholar
  39. 39.
    Atta, N.F., Darwish, S.A., Khalil, S.E., and Galal, A., Talanta, 2007, p. 1438.PubMedCrossRefGoogle Scholar
  40. 40.
    Nielsen, M.K. and Johansen, S.S., J. Anal. Toxicol., 2009, vol. 33, p. 212.PubMedCrossRefPubMedCentralGoogle Scholar
  41. 41.
    Goyal, R.N., Gupta, V.K., and Chatterjee, S., Sens. Actuators, B, 2010, vol. 149, p. 252.CrossRefGoogle Scholar
  42. 42.
    Fan, Y., Huang, K.J., Niu, D.J., Yang, C.P., and Jing, Q.S., Electrochim. Acta, 2011, vol. 56, p. 4685.CrossRefGoogle Scholar
  43. 43.
    Merli, D., Dondi, D., Pesavento, M., and Profumo, A., J. Electroanal. Chem., 2012, vol. 683, p. 103.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Electroanalytical Chemistry Laboratory, Faculty of Chemistry, University of GuilanRashtIran
  2. 2.Research House of Professor Reza, Education GuilanRashtIran

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