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Journal of Analytical Chemistry

, Volume 73, Issue 9, pp 917–921 | Cite as

Determination of Non-Narcotic Analgetics by HPLC with Preconcentration on Triton X-100 Induced Phases

  • O. I. FedorchukEmail author
  • S. A. Kulichenko
ARTICLES
  • 62 Downloads

Abstract

The induced micellar-extraction preconcentration of mefenamic acid, naproxen, and indomethacin on Triton X-100 phases in the presence of salicylic and benzoic acids is studied. The optimal conditions for the preconcentration of analgetics are found: the pH of the solutions and the concentration of analytes. The maximum extraction of analgetics is observed at pH < pKa of the analyte and modifier. An increase in the recovery of analgetics with a decrease in their concentration in the initial solution is shown. A procedure for the determination of non-narcotic analgetics by HPLC with preliminary micellar-extraction concentration on Triton X-100 induced phases is developed. The procedure was used to analyze an urine sample with additives.

Keywords:

non-narcotic analgetics Triton X-100 induced phases preconcentration HPLC 

Notes

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  1. 1.Chemistry Department, Taras Shevchenko Kiev National UniversityKievUkraine

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