A new sensitive spectrophotometric determination of sodium 2-mercaptoethanesulfonate using leuco xylene cyanol FF
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Abstract
A simple and accurate spectrophotometric method for determination of sodium 2-mercaptoethanesulfonate (MESNa) with leuco xylene cyanol FF (LXCFF) has been developed. The proposed method is based on the reaction of MESNa with potassium iodate(V) in acidic medium to liberate iodine, which oxidizes leuco xylene cyanol FF to its blue form xylene cyanol FF. The xylene cyanol FF dye formed shows maximum and stable absorbance at pH 4.1–4.2. Absorbance of the obtained colored products was measured at 613 nm. The molar absorptivity, limit of detection and limit of determination of the method were found to be 3.64 × 104 L/mol cm, 0.29 and 0.33 μg/mL, respectively. The colour system obeys Beer’s laws in the range 0.4–4.0 μg/mL of MESNa. All the variables were studied in order to optimize the reaction conditions. The procedure was used for determination of MESNa in pharmaceutical preparations. Reliability of determination was confirmed applying standard iodometric method, recommended by European and Polish Pharmacopoeia.
Keywords
sodium 2-sulfanylethanesulfonate sodium 2-mercaptoethanesulfonate leuco xylene cyanol FF spectrophotometry pharmaceutical analysisPreview
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References
- 1.Kuśmierek, K., Chwatko, G., Głowacki, R., and Bald, E., J. Chromatogr. B, 2009, vol. 877, p. 3300.CrossRefGoogle Scholar
- 2.Mare, S., Pneugonda, S., and Ercal, N., Biomed. Chromatogr., 2005, vol. 19, p. 80.CrossRefGoogle Scholar
- 3.Głowacki, R., Wójcik, K., and Bald E., J. Chromatogr. A, 2001, vol. 914, p. 29.CrossRefGoogle Scholar
- 4.Links, M. and Lewis, C., Drugs, 1999, vol. 57, p. 293.CrossRefGoogle Scholar
- 5.Nishikawa, A., Morsem, M.A., and Chung F.L., Cancer Lett., 2003, vol. 193, p. 11.CrossRefGoogle Scholar
- 6.Stofer-Vogel, B., Cerny, T., Kupfer, A., Junker, E., and Lauterburg, B.H., Br. J. Cancer, 1993, vol. 68, p. 590.CrossRefGoogle Scholar
- 7.Shusterman, T., Sela, S., Cohen, H., Kristal, B., Sbeit, W., and Reshef, R., Dig. Dis. Sci., 2003, vol. 48, p. 1177.CrossRefGoogle Scholar
- 8.Głowacki, R., Gryglik, D., Kuśmierek, K., and Bald, E., Talanta, 2005, vol. 66, p. 534.CrossRefGoogle Scholar
- 9.Etcal, N., Yang, P., and Aykin, N., J. Chromatogr. B, 2001, vol. 753, p. 287.CrossRefGoogle Scholar
- 10.Verschraagen, M., Bosma, M., Zwiers, T.H.U., and Torun, E., J. Chromatogr. B, 2003, vol. 783, p. 33.CrossRefGoogle Scholar
- 11.Verschraagen, M., Zwiers, T.H.U., De Koning, P., Welink, J., and Van der Vijgh, W.J.F., J. Chromatogr. B, 2001, vol. 753, p. 293.CrossRefGoogle Scholar
- 12.Ciesielski, W. and Skowron, M., Chem. Anal., 2004, vol. 49, p. 619.Google Scholar
- 13.Gatti, R., Cavrini, V., Roveri, P., and Pinzauti, S., J. Chromatogr., 1990, vol. 507, p. 451.CrossRefGoogle Scholar
- 14.Skrowron, M. and Ciesielski, W., Chem. Anal. (Warsaw), 2009, vol. 59, p. 743.Google Scholar
- 15.Kiran Kumar, T.N. and Revanasiddappa, H.D., Anal. Bioanal. Chem., 2003, vol. 376, p. 1126.CrossRefGoogle Scholar
- 16.Revanasiddappa, H.D. and Kiran Kumar, T.N., Anal. Bioanal. Chem., 2003, vol. 375, p. 319.Google Scholar
- 17.Revanasiddappa, H.D. and Kiran Kumar, T.N., Talanta, 2003, vol. 60, p. 1.CrossRefGoogle Scholar
- 18.Revanasiddappa, H.D. and Kiran Kumar, T.N., Anal. Sci., 2002, vol. 18, p. 1275.CrossRefGoogle Scholar
- 19.Pasha, C. and Narayana, B., Acta Chim. Slov., 2006, vol. 53, p. 77.Google Scholar
- 20.Buhl, F. and Gałkowska, M., J. Planar Chromatogr. Mod. TLC., 2006, vol. 19, p. 401.CrossRefGoogle Scholar
- 21.Buhl, F. and Gałkowska, M., Chem. Anal. (Warsaw), 2006, vol. 51, p. 623.Google Scholar
- 22.European Pharmacopoeia, 6th edition, Strasbourg (France), 2008, vol. 2.Google Scholar