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Journal of Analytical Chemistry

, Volume 67, Issue 2, pp 156–162 | Cite as

A carbositall electrode modified with a SiO2-hemoglobin-gold film as a promising biosensing element

  • T. S. Rozhanchuk
  • O. Yu. Tananaiko
  • E. A. Mazurenko
  • O. A. Egorov
Articles

Abstract

The analytical prospects of a carbositall electrode modified with a film based on SiO2, hemoglobin (Hb), and gold nanoparticles (CSE SiO2-Hb-Au), prepared by deposition with an electrically generated catalyst, are reported. Hemoglobin on the surface of CSE SiO2-Hb-Au is shown to possess electrocatalytic activity toward dissolved oxygen, giving a rationale for the development of a rapid voltammetric procedure of O2 quantification with a detection limit of 0.1 mg/L. The inhibition activity of a number of nitrogen-containing organic substances to the catalytic current CSE SiO2-Hb-Au is studied. A voltammetric procedure is proposed for determination of the anti-flu drug rimantadine, 1-(1-adamantyl)ethylamine hydrochloride, with a detection limit of 0.4 mg/L. The procedure is applicable to the quantification of rimantadine in blood serum and saliva.

Keywords

silicon oxide film carbositall electrode hemoglobin rimantadine voltammetry 

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • T. S. Rozhanchuk
    • 1
  • O. Yu. Tananaiko
    • 1
  • E. A. Mazurenko
    • 1
  • O. A. Egorov
    • 2
  1. 1.Faculty of ChemistryTaras Shevchenko Kiev National UniversityKievUkraine
  2. 2.VERKh-MS LaboratorySpoluka Chemical CompanyKievUkraine

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