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Journal of Analytical Chemistry

, Volume 64, Issue 5, pp 449–454 | Cite as

Spectrophotometric method for the determination of telmisartan with congo red

  • Zonghui QinEmail author
  • Weifen Niu
  • Rong Tan
Articles

Abstract

In pH 2.50 HCl-NaAc buffer solution, the reaction between telmisartan and congo red could form ionassociation complex, which has the maximum absorbance at 593 nm in the spectrophotometric experiment. Under this wavelength, the Beer’s law was obeyed within the concentration range of 1.08 × 10−6−2.24 × 10−5 M. The linear regression equation was A = −0.1913 × 105 c + 0.0286 (C: M). The regression coefficient r was 0.9986. The apparent molar coefficient ɛ593 was 1.63 × 104 L mol−1 cm−1 and the detection limit was 5.66 × 10−7 M. The established method having high sensitivity and good selectivity could be applied to the determination of telmisartan in pharmaceutical, urine and blood plasma samples with satisfactory results. The reaction mechanism was also discussed by using density functional theory methods. The result obtained was consilient with experimental data.

Keywords

Telmisartan Reagent Solution Sodium Dodecyl Benzene Sulfonate Blank Urine Sample Mole Ratio Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  1. 1.Department of Chemistry and Environmental ScienceYangtze Normal UniversityChongqing FulingP.R. China
  2. 2.Fuling Pharmaceutical FactoryTaiji GroupChongqing FulingP.R. China

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