Journal of Analytical Chemistry

, Volume 62, Issue 3, pp 266–269 | Cite as

Determination of acetaminophen by square wave voltammetry at a gold electrode modified by 4-amino-2-mercaptopyrimidine self-assembled monolayers

  • Li Jia
  • X. -H. Zhang
  • Q. Li
  • S. -F. Wang


A 4-Amino-2-mercaptopyrimidine self-assembled monolayer (AMP SAMs/Au) modified gold electrode was prepared. The electrochemical behavior of acetaminophen on the AMP SAMs/Au was studied in Britton-Robinson (BR) buffer solution. Compared to a bare gold electrode, the modified electrode exhibits a significant enhancement in the oxidation current response for acetaminophen. The modified electrode was used for the determination of acetaminophen by square wave voltammetry. The oxidation current increased linearly with the concentration of acetaminophen in the range of 2.0 × 10−6−4.0 × 10−3 M. The modified electrode made it possible to eliminate the interference of dopamine (DA), brucine, epinephrine (EP), and norepinephrine (NE). The practical analytical utility was illustrated by the determination of acetaminophen in a commercially available drug.


Acetaminophen Gold Electrode Oxidative Peak Current Bare Gold Wave Voltammetry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Mcgregir, A.H., More, L.J., Simpson, K.J., et al., J. Hum. Exp. Toxicol., 2003, vol. 22, no. 4, p. 221.CrossRefGoogle Scholar
  2. 2.
    Feng, Y.D., Wang, Y., and Xu, Y., Chin. J. Capital Normal Univ. (Nat. Sci. Ed.), 1998, vol. 19, no. 1, p. 50.Google Scholar
  3. 3.
    Wang, W.X., Zhou, S.Y., and Li, W.L., Chin. J. Fourth Milit. Med. Univ., 1997, vol. 18, no. 3, p. 241.Google Scholar
  4. 4.
    Liu, C.Y., Zhou, B.L., Fang, Y.X., et al., Chin. J. Anal. Test. Technol. Instrum., 1998, vol. 12, no. 4, p. 209.Google Scholar
  5. 5.
    Wang, Y., Chin. J. Chromatogr., 1999, vol. 17, no. 3, p. 268.Google Scholar
  6. 6.
    Yang, B.Y., Mo, J.Y., Yang, X.Y., et al., Chin. J. Chromatogr., 1999, vol. 17, no. 5, p. 477.Google Scholar
  7. 7.
    Zhou, J. and Wang, E., Anal. Chim. Acta, 1990, vol. 236, p. 293.CrossRefGoogle Scholar
  8. 8.
    Liang, Y.A. and Sun, J.H., Chin. J. Anal. Chem., 1994, vol. 22, no. 4, p. 359.Google Scholar
  9. 9.
    Erdogdu, G. and Karagozler, A.E., Talanta, 1997, vol. 44, no. 11, p. 2011.CrossRefGoogle Scholar
  10. 10.
    Zen, J.M. and Ting, Y.S., Anal. Chim. Acta, 1997, vol. 342, nos. 2–3, p. 175.CrossRefGoogle Scholar
  11. 11.
    Huang, S.S., Tang, H., and Li, B.F., J. Mikrochim. Acta, 1998, vol. 128, nos. 1–2, p. 37.CrossRefGoogle Scholar
  12. 12.
    Wang, Z.H., Zhang, Y.H., Zhou, S.P., and Chinese, J., Acta Pharm. Sin., 2001, vol. 36, no. 11, p. 840.Google Scholar
  13. 13.
    Wang, S.F., Du, D., and Zou, Q.C., Talanta, 2002, vol. 57, p. 687.CrossRefGoogle Scholar
  14. 14.
    Zhang, X.H. and Wang, S.F., Sensors, 2003, vol. 3, p. 61.CrossRefGoogle Scholar
  15. 15.
    Jia, Li, Lei, Q.F., Zhang, X.H., et al., Chin. J. Appl. Chem., 2005, vol. 2, p. 172.Google Scholar
  16. 16.
    Bard, A.J. and Faulkner, L.R., Electrochemical Methods: Fundamentals and Applications, New York: Wiley, 1980.Google Scholar
  17. 17.
    Ding, S.J. and Zhang, Z.X., Chem. J. Chin. Univ., 1991, vol. 12, p. 598.Google Scholar
  18. 18.
    Kissinger, P.T., Roston, D.A., Van Benschoten, J.J., et al., J. Chem. Educ., 1983, vol. 60, p. 772.CrossRefGoogle Scholar
  19. 19.
    Miner, D.J., Rice, J.R., and Riggin, R.M., Anal. Chem., 1981, vol. 53, p. 2258.CrossRefGoogle Scholar
  20. 20.
    Sandulescu, R., Mirel, S., and Oprean, R., J. Pharm. Biomed. Anal., 2000, vol. 23, p. 77.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2007

Authors and Affiliations

  • Li Jia
    • 1
  • X. -H. Zhang
    • 1
  • Q. Li
    • 1
  • S. -F. Wang
    • 1
  1. 1.Faculty of Chemistry and Material ScienceHubei UniversityWuhanChina

Personalised recommendations