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How miRNA Structure of Animals Influences Their Biogenesis

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Abstract

MicroRNAs are small noncoding RNAs that are involved in the post-transcriptional regulation of the gene expression in various organisms. This article reviews recent advances in understanding the role of the primary and secondary structures of animal miRNA precursors through the biogenesis stages and the miRNA maturation steps. Also, we describe the effects of genetic variability and heterogeneity of miRNA ends, which play an important role in epitranscriptomics as well as annotation errors in the miRNA databases.

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Funding

This work was supported by the state budget project 0324-2019-0040.

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Correspondence to P. S. Vorozheykin.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Vorozheykin, P.S., Titov, I.I. How miRNA Structure of Animals Influences Their Biogenesis. Russ J Genet 56, 17–29 (2020). https://doi.org/10.1134/S1022795420010135

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Keywords:

  • miRNA
  • pre-miRNA
  • secondary structure
  • biogenesis
  • mirtron
  • single nucleotide polymorphism
  • mutation
  • epigenetics