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MicroRNAs Associated with Preeclampsia

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Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs that play an important role in the mRNA regulation translation and degradation. Recent studies uncovered the implication of miRNA in the development of preeclampsia (PE)—a common and potentially fatal complication in pregnancy. This review provides an analysis of the current knowledge on miRNA associated with PE. We discuss the potential for using miRNA for the early diagnosis and prevention of PE. We briefly describe the miRNA targets associated with PE and point out the most promising PE predictors.

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Fig. 1.

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Funding

The study was conducted with the financial support of the topic of fundamental scientific research no. 0558-2017-0056.

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Correspondence to E. S. Vashukova.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by I. Grishina

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Vashukova, E.S., Glotov, A.S. & Baranov, V.S. MicroRNAs Associated with Preeclampsia. Russ J Genet 56, 1–16 (2020). https://doi.org/10.1134/S1022795419080167

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Keywords:

  • miRNA
  • pregnancy
  • preeclampsia
  • biomarkers