Russian Journal of Genetics

, Volume 52, Issue 1, pp 17–28 | Cite as

Mutation induction in the mouse and human germline

  • Yu. E. Dubrova
Reviews and Theoretical Articles


The review describes the effects of exposure to mutagens on mutation induction in human and mouse germlines. The results of studies that evaluated inductions of mutations in human families subjected to irradiation are presented and discussed. The effects of exposure to mutagens on mutation induction in the mouse germline are also considered. We analyze and discuss the recent data on the genome-wide effects of irradiation on mutation induction in the mouse germline obtained by next-generation sequencing and comparative genome hybridization.


mutation mutagens germ cells human mouse 


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© Pleiades Publishing, Inc. 2016

Authors and Affiliations

  1. 1.Department of GeneticsLeicester UniversityLeicesterUnited Kingdom
  2. 2.Vavilov Institute of General GeneticsRussian Academy of SciencesMoscowRussia

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