Russian Journal of Genetics

, Volume 49, Issue 2, pp 214–219 | Cite as

The pleiotropic effect of selection for behavior on coat color in grey rats (Rattus norvegicus)

  • L. A. Prasolova
  • I. N. Oskina
  • I. Z. Plyusnina
Animal Genetics


The effects of selection for a type of behavior relative to humans (tame and aggressive) on the intensity of coat color in agouti rats with the AAHH genotype were studied. Animals that were not under selection for behavior (wild animals) were used as the control. Morphometric analysis of the hair parameters that influence the intensity of coat color demonstrated that, on the one hand, polymorphism in the main coat color exists in the population of wild agouti rats, that is, both light and dark agouti animals exist. On the other hand, it was demonstrated that selection for a type of behavior in rats is accompanied by selection of animals that differ in the intensity of the main genetically identical coat color. Dark-colored animals are more prevelent among the aggressive animals, while light-colored animals prevail among tame animals. The association of the effects of selection for behavior with the modification of coat color is probably caused by the presence of common neurohormonal mechanisms for the regulation of these processes.


Coat Color Hair Color Color Morph American Mink Main Color 
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  1. 1.
    Ducrest, A., Keller, L., and Roulin, A., Pleiotropy in the Melanocortin System Coloration and Behavioural Syndromes, Trends Ecol. Evol., 2008, no. 9, pp. 502–510.Google Scholar
  2. 2.
    Gulevich, R.G., Oskina, I.N., Shikhevich, S.G., et al., Effect of Selection for Behavior on Pituitary-Adrenal Axis and Proopiomelanocortin Gene Expression on Silver Foxes (Vulpes vulpes), Physiol. Behav., 2004, vol. 82, pp. 513–518.PubMedCrossRefGoogle Scholar
  3. 3.
    Hoekstra, H.E., Genetics Development and Evolution of Adaptive Pigmentation in Vertebrates, Heredity, 2006, vol. 97, pp. 222–234.PubMedCrossRefGoogle Scholar
  4. 4.
    Price, T. and Pavelka, M., Evolution of a Color Pattern: History Development and Selection, J. Evol. Biol., 1996, vol. 9, pp. 451–470.CrossRefGoogle Scholar
  5. 5.
    Bazhan, N.M., Polymorphism of the Fur Pigmentation Genes and the Hormonal Adaptation System in the Water Vole (Arvicola terrestris), Izv. Akad. Nauk SSSR, Ser. Biol., 1991, no. 3, pp. 363–367.Google Scholar
  6. 6.
    Keeler, C.E., The Association of the Black (nonagouti) Gene with Behavior in the Norway Rat, J. Hered., 1942, vol. 33, no. 12, pp. 371–384.Google Scholar
  7. 7.
    Wilcock, J., Gene Action and Behavior on Evolution of Major Gene Pleiotropism, Physiol. Bull., 1969, vol. 72, no. 1, pp. 1–29.Google Scholar
  8. 8.
    Trut, L.N., Plyusnina, I.Z., and Prasolova, L.A., Mutations hooded and nonagouti among Wild Norway Rats (Rattus norvegicus): Selection at Behavior and Photoperiod, Russ. J. Genet., 2000, vol. 30, no. 6, pp. 813–822.Google Scholar
  9. 9.
    Belyaev, D., Ruvinsky, A., and Trut, L., Inherited Activation—Inactivation of the Star Gene in Foxes, J. Hered., 1981, vol. 72, no. 4, pp. 264–274.Google Scholar
  10. 10.
    Gulevich, R.G., Plyusnina, I.Z., Prasolova, L.A., et al., White Spotting in Norway Rats Selected for Tame Behavior, J. Zool., 2010, vol. 280, pp. 264–270.CrossRefGoogle Scholar
  11. 11.
    Trapezov, O., Black crystal a Novel Color Mutant American Mink (Mustela vison Schr.), J. Hered., 1997, vol. 88, no. 2, pp. 164–166.PubMedCrossRefGoogle Scholar
  12. 12.
    Trut, L., Early Canid Domestication: The Farm-Fox Experiment, Am. Sci., 1999, vol. 87, no. 2, pp. 160–169.Google Scholar
  13. 13.
    Belyaev, D.K., Trut, L.N., and Ruvinskii, A.E., Allelic Relationships between the Georgian white, platinum and white face Mutations in Foxes, Genetika (Moscow), 1973, vol. 9, no. 10, pp. 71–77.Google Scholar
  14. 14.
    Zvereva, L.P., Belyaev, D.K., and Privalova, G.N., Phenogenetic Analysis of Pigmentation in American Mink (Mustela vison Schr.) Mutants: 2. Effect of Aleutian Mutation and Interaction of the Aleutian and Silver-Blue Color in the Sapphire Mink Genotype: Influence of “stuart” Factor on the Hair Pigmentation, Genetika (Moscow), 1976, vol. 2, no. 2, pp. 104–109.Google Scholar
  15. 15.
    Plyusnina, I.Z., Trut, L.N., Karpushkeeva, N.I., et al., Some Behavioral and Physiological Characteristics of nonagouti Mutation in Gray Rats during Selection for Aggressiveness, Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2003, vol. 53, no. 5, pp. 613–621.Google Scholar
  16. 16.
    Trut, L.N., Plyusnina, I.Z., Prasolova, L.A., and Kim, A.A., The hooded Allele and Selection of Wild Norway Rats Rattus norvegicus for Behavior, Russ. J. Genet., 1997, vol. 33, no. 8, pp. 983–989.Google Scholar
  17. 17.
    Gershenzon, M.S., Genetic Polymorphism in an Animal Population and Its Evolutional Value, Zh. Obshch. Biol., 1974, vol. 35, no. 5, pp. 678–684.PubMedGoogle Scholar
  18. 18.
    Klungland, H. and Vage, D.I., Molecular Genetics of Pigmentation in Domestic Animals, Curr. Genomics, 2000, vol. 1, pp. 223–242.CrossRefGoogle Scholar
  19. 19.
    Haussen, V., Gunawardhana, S., and Meyer, J., The agouti coat—Color Locus May Influence Brain Catecholamines Regional Differences in Norepinerphine and Dopamine in the Brains of Two Color-Morphs of Deer Mice (Peromyscus maniculatus), Comp. Biochem. Physiol., 1994, vol. 107, pp. 51–55.Google Scholar
  20. 20.
    Naumenko, E.V., Popova, N.K., Nikulina, E.M., et al., Behavior Adrenocortical Activity and Brain Monoamines in Norway Rats Selected for Aggressiveness Towards Man, Pharmacol. Biochem. Behav., 1989, no. 33, pp. 85–91.Google Scholar
  21. 21.
    Plyusnina, I.Z. and Os’kina, I.N., Ontogenesis of Behavior and the Selection for Domestication of Wild Norway Rats Rattus norvegicus, Sovremennye kontseptsii evolyutsionnoi genetiki (Modern Concepts of Evolutionary Genetics), Novosibirsk: Institut tsitologii i genetiki Sibirskoe Otd. Ross. Akad. Nauk, 2000, pp. 341–349.Google Scholar
  22. 22.
    Slominski, A., Tobin, D., Shibahara, S., and Wortsman, J., Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation, J. Physiol. Rev., 2004, vol. 84, pp. 1156–1228.Google Scholar
  23. 23.
    Os’kina, I.N. and Plyusnina, I.Z., Pituitary-Adrenal System under Selection for Domestication Behavior, Sovremennye kontseptsii evolyutsionnoi genetiki (Modern Concepts of Evolutionary Genetics), Novosibirsk: Inst. Tsitol. Genet. Sib. Otd. Ross. Akad. Nauk, 2000, pp. 327–334.Google Scholar
  24. 24.
    Wolf, G.L., Kodell, R.L., Moore, S.R., and Cooney, G.A., Maternal Epigenetics and Methyl Supplements Affect agouti Gene Expression in Avy/a Mice, FASEB, 1998, pp. 949–957.Google Scholar
  25. 25.
    Vanyushin, B.F., DNA Methylation and Epigenetics, Russ. J. Genet., 2006, vol. 42, no. 9, pp. 1186–1199.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • L. A. Prasolova
    • 1
  • I. N. Oskina
    • 1
  • I. Z. Plyusnina
    • 1
  1. 1.Institute of Cytology and Genetics, Siberian BranchRussian Academy of SciencesNovosibirskRussia

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