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Russian Journal of Genetics

, Volume 48, Issue 7, pp 755–757 | Cite as

Polymorphisms associated with sickle cell disease in Southern Iran

  • S. Haghpanah
  • Sh. Nasirabadi
  • M. Kianmehr
  • A. Afrasiabi
  • M. Karimi
Short Communications
  • 76 Downloads

Abstract

Sickle cell disease (SCD) is an inherited autosomal recessive disorder. We aimed to describe the spectrum of haplotypes of BS-gene and to investigate a relationship with disease phenotype in patients with SCD in Southern Iran. We didn’t find any significant association between BS-globin gene haplotypes and clinical severity of the disease in an Iranian population. The exact mechanism by which the BS-globin gene polymorphism affects clinical presentation is not obvious; however, further detailed studies at the molecular level, with a larger sample size are required to show the mechanisms that influence the clinical presentation of SCD in Iranian population.

Keywords

Sickle Cell Globin Gene Priapism Iranian Population Sickle Cell Anemia Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • S. Haghpanah
    • 1
  • Sh. Nasirabadi
    • 1
  • M. Kianmehr
    • 1
  • A. Afrasiabi
    • 1
  • M. Karimi
    • 1
  1. 1.Hematology Research CentreShiraz University of Medical SciencesShirazIran

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