Russian Journal of Genetics

, Volume 48, Issue 7, pp 755–757 | Cite as

Polymorphisms associated with sickle cell disease in Southern Iran

  • S. Haghpanah
  • Sh. Nasirabadi
  • M. Kianmehr
  • A. Afrasiabi
  • M. Karimi
Short Communications


Sickle cell disease (SCD) is an inherited autosomal recessive disorder. We aimed to describe the spectrum of haplotypes of BS-gene and to investigate a relationship with disease phenotype in patients with SCD in Southern Iran. We didn’t find any significant association between BS-globin gene haplotypes and clinical severity of the disease in an Iranian population. The exact mechanism by which the BS-globin gene polymorphism affects clinical presentation is not obvious; however, further detailed studies at the molecular level, with a larger sample size are required to show the mechanisms that influence the clinical presentation of SCD in Iranian population.


Sickle Cell Globin Gene Priapism Iranian Population Sickle Cell Anemia Patient 
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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • S. Haghpanah
    • 1
  • Sh. Nasirabadi
    • 1
  • M. Kianmehr
    • 1
  • A. Afrasiabi
    • 1
  • M. Karimi
    • 1
  1. 1.Hematology Research CentreShiraz University of Medical SciencesShirazIran

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