Russian Journal of Genetics

, Volume 48, Issue 4, pp 477–479 | Cite as

Frequencies of functional caspase 12 genotypes in the North-Africa population

  • A. D. Kempińska-Podhorodecka
  • O. M. Knap
  • K. Kobus
  • A. Ciechanowicz
Short Communications


Caspase 12 (Csp-12) is a cysteine protease that plays a role in regulation of cytokine maturation. It is present either in a functional full-length variant (Csp-12L) that predisposes to a lower immune response or in an inactive, common version (Csp-12S) that contains a stop codon that results in a truncated form. Genomic DNA from unrelated North Africans, residents of 4th Nile Cataract Region in Sudan, was analyzed. One hundred umbilical blood samples of Polish newborns served as a reference group from the Caucasian population. The analysis of stop-codon polymorphism performed on the 212 human samples from Northern Sudan identified 6.6% individuals with heterozygous genotypes while not one homozygous Csp-12L was found. All examined Polish individuals were homozygous Csp-12S.


Yersinia Pestis Umbilical Cord Blood Sample Lower Immune Response Light Chain Enhancer Cytokine Maturation 
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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • A. D. Kempińska-Podhorodecka
    • 1
  • O. M. Knap
    • 2
  • K. Kobus
    • 1
  • A. Ciechanowicz
    • 3
  1. 1.Medical Biology LaboratoryPomeranian Medical UniversitySzczecinPoland
  2. 2.Independent Laboratory of Disaster MedicinePomeranian Medical UniversitySzczecinPoland
  3. 3.Department of Clinical and Molecular BiochemistryPomeranian Medical UniversitySzczecinPoland

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