Russian Journal of Genetics

, Volume 47, Issue 12, pp 1496–1498 | Cite as

CYP2E1 gene polymorphism and ovarian cancer risk in the Yakut population

  • A. V. Khrunin
  • F. G. Ivanova
  • A. A. Moiseev
  • V. A. Gorbunova
  • S. A. Limborska
Short Communications


The CYP2E1 gene polymorphism has been studied in Yakut women with ovarian cancer and without cancer. The two groups have been found to substantially differ in the frequency of the CYP2E1*1D allele (with a 96-bp insertion in the promoter region of the gene): it is more frequent in healthy women (16.3 versus 7.4%, P = 0.007).


Ovarian Cancer Ovarian Cancer Patient Ovarian Cancer Risk Chlor Zoxazone CYP2E1 Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bolt, H.M., Roos, P.H., and Their, R., The Cytochrome P-450 Isoenzyme CYP2E1 in the Biological Processing of Industrial Chemicals: Consequences for Occupational and Environmental Medicine, Int. Arch. Occup. Environ. Health, 2003, vol. 76, no. 3, pp. 174–185.PubMedGoogle Scholar
  2. 2.
    Gemma, S., Vichi, S., and Testai, E., Individual Susceptibility and Alcohol Effects: Biochemical and Genetic Aspects, Ann. Ist. Super Sanita, 2006, vol. 42, no. 1, pp. 8–16.PubMedGoogle Scholar
  3. 3.
    Caro, A.A. and Cederbaum, A.I., Oxidative Stress, Toxicology, and Pharmacology of CYP2E1, Annu. Rev. Pharmacol. Toxicol., 2004, vol. 44, pp. 27–42.PubMedCrossRefGoogle Scholar
  4. 4.
    Danko, I.M. and Chaschin, N.A., Association of CYP2E1 Gene Polymorphism with Predisposition to Cancer Development, Exp. Oncol., 2005, vol. 27, no. 4, pp. 248–256.PubMedGoogle Scholar
  5. 5.
    Neafsey, P., Ginsberg, G., Hattis, D. et al., Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity, J. Toxicol. Environ. Health, Ser. B Crit. Rev., 2009, vol. 12, nos. 5–6, pp. 362–388.CrossRefGoogle Scholar
  6. 6.
    Milligan, B.G., Total DNA Isolation, Molecular Genetic Analysis of Populations, Hoelzel, A.R., Ed., London: Oxford Univ. Press, 1998, pp. 29–60.Google Scholar
  7. 7.
    Khrunin, A.V., Moisseev, A., Gorbunova, V., and Limborska, S., Genetic Polymorphisms and the Efficacy and Toxicity of Cisplatin-Based Chemotherapy in Ovarian Cancer Patients, Pharmacogenomics J., 2010, vol. 10, no. 1, pp. 54–61.PubMedCrossRefGoogle Scholar
  8. 8.
    Liu, K. and Muse, S.V., PowerMarker: An Integrated Analysis Environment for Genetic Marker Analysis, Bioinformatics, 2005, vol. 21, no. 9, pp. 2128–2129.PubMedCrossRefGoogle Scholar
  9. 9.
    Fritsche, E., Pittman, G.S., and Bell, D.A., Localization, Sequence Analysis, and Ethnic Distribution of a 96-bp Insertion in the Promoter of the Human CYP2E1 Gene, Mutat. Res. Genomics, 2000, vol. 432, pp. 1–5.CrossRefGoogle Scholar
  10. 10.
    Nomura, F., Itoga, S., Uchimoto, T. et al., Transcriptional Activity of the Tandem Repeat Polymorphism in the 5′-Flanking Region of the Human CYP2E1 Gene, Alcohol Clin. Exp. Res., 2003, vol. 27, no. 8, suppl., pp. 42S–46S.PubMedCrossRefGoogle Scholar
  11. 11.
    Uchimoto, T., Itoga, S., Nezu, M., et al., Role of the Genetic Polymorphisms in the 5′-Flanking Region for Transcriptional Regulation of the Human CYP2E1 Gene, Alcohol Clin. Exp. Res., 2007, vol. 31, no. 1, pp. 36S–42S.CrossRefGoogle Scholar
  12. 12.
    Marchand, L.L., Wilkinson, G.R., and Wilkens, L.R., Genetic and Dietary Predictors of CYP2E1 Activity: A Phenotyping Study in Hawaii Japanese Using Chlorzoxazone, Cancer Epidemiol. Biomarkers Prev., 1999, vol. 8, no. 6, pp. 495–500.PubMedGoogle Scholar
  13. 13.
    Itoga, S., Nomura, F., Makino, Y., et al., Tandem Repeat Polymorphism of the CYP2E1 Gene: An Association Study with Esophageal Cancer and Lung Cancer, Alcohol Clin. Exp. Res., 2002, vol. 26, no. 8, suppl., pp. 15S–19S.PubMedCrossRefGoogle Scholar
  14. 14.
    Morita, M., Le Marchand, L., Kono, S., et al., Genetic Polymorphisms of CYP2E1 and Risk of Colorectal Cancer: The Fukuoka Colorectal Cancer Study, Cancer Epidemiol. Biomarkers Prev., 2009, vol. 18, no. 1, pp. 235–241.PubMedCrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • A. V. Khrunin
    • 1
  • F. G. Ivanova
    • 2
  • A. A. Moiseev
    • 3
  • V. A. Gorbunova
    • 3
  • S. A. Limborska
    • 1
  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia
  2. 2.Yakut Republican Cancer ClinicYakutskRussia
  3. 3.Blokhin Russian Cancer Research CenterRussian Academy of Medical SciencesMoscowRussia

Personalised recommendations