Russian Journal of Genetics

, 47:1117 | Cite as

Genes expression of metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis

  • N. L. Starodubtseva
  • V. V. Sobolev
  • A. G. Soboleva
  • A. A. Nikolaev
  • S. A. Bruskin
Human Genetics


Using real-time polymerase chain reaction (RT-PCR), we measured mRNA amounts of matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-9, and MMP-12 genes in psoriatic lesions and unaffected skin of the same patients. We observed significant (about 15-fold) increase in the expression level of matrix metalloproteinase MMP-1 and MMP-12 genes associated with psoriasis. The results of our studies of MMP gene expression in cultured primary human keratinocytes treated with interleukin (IL)-17 have shown upregulation of MMP gene expression both in cultured keratinocytes and in psoriatic skin lesions. Therefore, upregulation of MMP genes in the skin affected by psoriasis could result from IL-17 effects on skin cells.


Psoriasis Psoriasis Patient Psoriatic Lesion Primary Keratinocytes Primary Human Keratinocytes 
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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • N. L. Starodubtseva
    • 1
  • V. V. Sobolev
    • 2
  • A. G. Soboleva
    • 2
  • A. A. Nikolaev
    • 2
  • S. A. Bruskin
    • 2
  1. 1.Moscow Institute of Physics and TechnologyMoscowRussia
  2. 2.Vavilov Institute of General GeneticsRussian Academy of SciencesMoscowRussia

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