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Russian Journal of Genetics

, Volume 46, Issue 12, pp 1492–1499 | Cite as

Gene pool of Daghestan ethnic groups: Polymorphism of classical gene markers in the Darghin ethnic group

  • M. O. Radzhabov
  • I. A. Shamov
  • D. G. Gasaev
  • I. V. Goldenkova-Pavlova
  • I. N. Shilnikova
  • Yu. V. Shneider
Short Communications
  • 39 Downloads

Abstract

The work is part of a study of the gene pool for Daghestan ethnic groups. In total, 38 alleles and eight genotypes were studied at 14 loci (AB0, Rhesus, P, Lewis, Kell, PH, GC, C′3, TF, 6-PGD, GLO1, ESD, ACP, and PBM1) of immunogenetic and biochemical polymorphic gene systems. A high frequency of allele d of the Rhesus system was observed in all populations examined (0.399–0.474). Among the rare haplotypes of the Rhesus system, we observed CDE in the Degva population, Cde in the Sergokala and Degva populations, and cdE in the Sergokala and Vanashimakhi populations. The typical Caucasian ACP1 c allele of the ACP1 locus, which is rather uncommon, was observed at a relatively high frequency in three (Segokala, Vanashimakhi, and Gubden) of the four local populations under study. In the Lewis system, a high frequency of the Le(a+b+) phenotype, which is characteristic of early childhood, was detected in the adult populations of Sergokala and Degva. The rare PGM 1 V allele of the phosphoglucomutase 1 system (PGM1) was additionally observed in the Sergokala population. Statistical analysis identified 19 cases where the observed phenotype frequencies significantly differed from the frequencies expected from the Hardy-Weinberg equilibrium.

Keywords

Ethnic Group Phosphoglucomutase Vavilov Institute Indigenous Ethnic Group Gene Pool Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • M. O. Radzhabov
    • 1
  • I. A. Shamov
    • 2
  • D. G. Gasaev
    • 3
  • I. V. Goldenkova-Pavlova
    • 4
  • I. N. Shilnikova
    • 4
  • Yu. V. Shneider
    • 4
  1. 1.Department of Nature ManagementDaghestan State UniversityMakhachkala, DaghestanRussia
  2. 2.Daghestan State Medical AcademyMakhachkala, DaghestanRussia
  3. 3.Daghestan Republican Central Clinical HospitalMakhachkala, DaghestanRussia
  4. 4.Vavilov Institute of General GeneticsRussian Academy of SciencesMoscowRussia

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