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Russian Journal of Genetics

, Volume 46, Issue 10, pp 1233–1235 | Cite as

Role of G(-43)A polymorphism in the promoter region of the Xist gene in non-random x-chromosome inactivation in intraspecific hybrid voles

  • K. E. Orischenko
  • E. A. Elisaphenko
  • S. M. Zakian
Article
  • 34 Downloads

Abstract

Interaction of transcription factor CTCF with the minimal promoter of Xist gene was investigated in intraspecific hybrids of common voles. CTCF was shown to bind with the minimal promoter region in vivo. However, the EMSA experiments resulted in the absence of interaction between the CTCF factor and its potential binding site. Probably, G(-43)A substitution influences binding efficacy of another transcription factor such as activator protein 2, AP2.

Keywords

Inner Cell Mass Minimal Promoter Common Vole CTCF Binding Potential Binding Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • K. E. Orischenko
    • 1
  • E. A. Elisaphenko
    • 1
  • S. M. Zakian
    • 1
  1. 1.Institute of Cytology and Genetics, Siberian BranchRussian Academy of SciencesNovosibirskRussia

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