Russian Journal of Genetics

, Volume 46, Issue 9, pp 1067–1069 | Cite as

LTR retrotransposons as source of promoters in the drosophila genome

  • I. V. MakuninEmail author
  • A. A. Yurlova


Mobile genetic elements affect genome structure and function in various ways. Significant number of genes in human and mouse are transcribed from alternative promoters located in LTR retrotransposons. As a rule, these retrotransposons are located upstream of annotated genes, and their promoters initiate transcription of alternative first exons. We investigated role of LTR retrotransposons in expression of genes in Drosophila. Using database of spliced ESTs we identified only 13 potential cases of transcription initiation from long terminal repeats of LTR retrotransposons within euchromatic part of the Drosophila genome. Our results indicate on insignificant role of promoters of LTR retrotransposons in expression of genes in Drosophila.


Transposable Element Terminal Repeat UCSC Genome Browser Mouse Oocyte Drosophila Genome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Oliver, K.R. and Greene, W.K., Transposable Elements: Powerful Facilitators of Evolution, BioEssays, 2009, vol. 31, no. 7, pp. 703–714.CrossRefPubMedGoogle Scholar
  2. 2.
    Kovalskaya, E., Buzdin, A., Gogvadze, E., et al., Functional Human Endogenous Retroviral LTR Transcription Start Sites Are Located between the R and U5 Regions, Virology, 2006, vol. 346, no. 2, pp. 373–378.CrossRefPubMedGoogle Scholar
  3. 3.
    Buzdin, A., Kovalskaya-Alexandrova, E., Gogvadze, E., and Sverdlov, E., At Least 50% of Human-Specific HERV-K (HML-2) Long Terminal Repeats Serve in vivo as Active Promoters for Host Nonrepetitive DNA Transcription, J. Virol., 2006, vol. 80, no. 21, pp. 10752–10762.CrossRefPubMedGoogle Scholar
  4. 4.
    Dunn, C.A., Medstrand, P., and Mager, D.L., An Endogenous Retroviral Long Terminal Repeat Is the Dominant Promoter for Human Beta1,3-Galactosyl-transferase 5 in the Colon, Proc. Natl. Acad. Sci. USA, 2003, vol. 100, no. 22, pp. 12841–12846.CrossRefPubMedGoogle Scholar
  5. 5.
    Peaston, A.E., Knowles, B.B., and Hutchison, K.W., Genome Plasticity in the Mouse Oocyte and Early Embryo, Biochem. Soc. Trans., 2007, vol. 35, no. 3, pp. 618–622.CrossRefPubMedGoogle Scholar
  6. 6.
    van de Lagemaat, L.N., Landry, J.R., Mager, D.L., and Medstrand, P., Transposable Elements in Mammals Promote Regulatory Variation and Diversification of Genes with Specialized Functions, Trends Genet., 2003, vol. 19, no. 10, pp. 530–536.CrossRefPubMedGoogle Scholar
  7. 7.
    Kaminker, J.S., Bergman, C.M., Kronmiller, B., et al., The Transposable Elements of the Drosophila melanogaster Euchromatin: A Genomics Perspective, Genome Biol., 2002, vol. 3, no. 12, p. RESEARCH0084.CrossRefPubMedGoogle Scholar
  8. 8.
    Deloger, M., Cavalli, F.M., Lerat, E., et al., Identification of Expressed Transposable Element Insertions in the Sequenced Genome of Drosophila melanogaster, Gene, 2009, vol. 439, nos. 1–2, pp. 55–62.CrossRefPubMedGoogle Scholar
  9. 9.
    Kuhn, R.M., Karolchik, D., Zweig, A.S., et al., The UCSC Genome Browser Database: Update 2009, Nucleic Acids Res., 2009, vol. 37, pp. D755–D761.CrossRefPubMedGoogle Scholar
  10. 10.
    Lipatov, M., Lenkov, K., Petrov, D.A., and Bergman, C.M., Paucity of Chimeric Gene-Transposable Element Transcripts in the Drosophila melanogaster Genome, BMC Biol., 2005, vol. 3, p. 24.CrossRefPubMedGoogle Scholar
  11. 11.
    Peaston, A.E., Evsikov, A.V., Graber, J.H., et al., Retrotransposons Regulate Host Genes in Mouse Oocytes and Preimplantation Embryos, Dev. Cell, 2004, vol. 7, no. 4, pp. 597–606.CrossRefPubMedGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Institute of Chemical Biology and Fundamental Medicine, Siberian BranchRussian Academy of ScienceNovosibirskRussia

Personalised recommendations