Russian Journal of Genetics

, Volume 46, Issue 4, pp 385–393

Meiotic inactivation of sex chromosomes in mammals

  • E. A. Vaskova
  • S. V. Pavlova
  • A. I. Shevchenko
  • S. M. Zakian
Reviews and Theoretical Articles
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Abstract

During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X-chromosome preserves inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which is observed in mammalian females at early embryogenetic stages.

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • E. A. Vaskova
    • 1
  • S. V. Pavlova
    • 1
  • A. I. Shevchenko
    • 1
  • S. M. Zakian
    • 1
  1. 1.Institute of Cytology and Genetics, Siberian BranchRussian Academy of SciencesNovosibirskRussia

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