Russian Journal of Genetics

, Volume 46, Issue 2, pp 224–229

Syntropic genes of allergic diseases

Human Genetics


Common (syntropic) genes of allergic diseases (ADs) HLA-DQB1, HLA-DRB1, IL4, IL4RA, MS4A2, HLA-DQA1, LTC4S, IL13, IL10, and TGFB1 have been identified on the basis of information from the HuGENet internet database. The functional realm of these genes is associated mainly with the initiation and regulation of an immune response and inflammation. Importance of these processes in the development of ADs is underlined. The results of cluster analysis of allergic diseases obtained using the data on common genes predisposing to their development are presented. Genetic clusterization of ADs confirms their accepted clinical classification.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pfaundler, M. und von Seht, L., Weiteres uber Syntropie kindlicher Krankheitzustande, Zeitschrift Kinderheilk., 1921, vol. 30, pp. 298–313.Google Scholar
  2. 2.
    Bouchard, Ch., Lecons sur les maladies par ralentissement de la nutrition, Paris, 1890.Google Scholar
  3. 3.
    Puzyrev, V.P., Genetic View on the Phenomenon of Combined Pathology in Humans, Med. Genet., 2008, vol. 7, no. 9, pp. 3–9.Google Scholar
  4. 4.
    Puzyrev, V.P., Stepanov, V.A., and Makeeva, O.A., Syntropie Genes of Cardiovascular Disease Continuum, Med. Genet., 2009, vol. 8, no. 3, pp. 31–38.Google Scholar
  5. 5.
    McKusick, V.A., On Lumpers and Splitters or the Nosology of Genetic Disease, Birth Defects, 1969, vol. 5, pp. 23–32.Google Scholar
  6. 6.
    Biesecker, L.G., Lumping and Splitting: Molecular Biology in the Genetics Clinic, Clin. Genet., 1998, vol. 53, pp. 3–7.CrossRefPubMedGoogle Scholar
  7. 7.
    Brunner, H.G. and van Driel, M.A., From Syndrome Families to Functional Genomics, Nat. Genet., 2004, vol. 5, pp. 545–551.CrossRefGoogle Scholar
  8. 8.
    Yu, W., Gwinn, M., Clyne, M., et al., A Navigator for Human Genome Epidemiology, Nat. Genet., 2008, vol. 40, pp. 124–125.CrossRefPubMedGoogle Scholar
  9. 9.
    Johansson, S.G.O., Hourinehane, J.O.B., Bousquet, J., et al., A Revised Nomenclature for Allergy: An EAACI Position Statement from the EAACI Nomenclature Task Force, Allergy, 2001, vol. 56, pp. 813–824.CrossRefPubMedGoogle Scholar
  10. 10.
    Ellis, Ch.N., Drake, L.A., Prendergast, M.M., et al., Validation of Expert Opinion in Identifying Comorbidities Associated with Atopic Dermatitis/Eczema, Phar-macoeconomics, 2003, vol. 21, pp. 875–883.CrossRefGoogle Scholar
  11. 11.
    Annesi-Maesano, I., Beyer, A, Marmouz, F, et al., Concurrent Allergic Diseases, a Cross-Sectional Study in a French Population, Allergy, 2006, vol. 61, pp. 390–391.CrossRefPubMedGoogle Scholar
  12. 12.
    Ricci, G., Patrizi, A, Baldi, E., et al., Long-Term Follow-up of Atopic Dermatitis: Retrospective Analysis of Related Risk Factors and Association with Concomitant Allergic Diseases, J. Am. Acad. Dermatol., 2006, vol. 55, pp. 765–771.CrossRefPubMedGoogle Scholar
  13. 13.
    Kapoor, R., Chandrakala, M., Hoffstad, O., et al., The Prevalence of Atopic Triad in Children with Physician-Confirmed Atopic Dermatitis, J. Am. Acad. Dermatol., 2008, vol. 58, pp. 68–73.CrossRefPubMedGoogle Scholar
  14. 14.
    Yuksel, H., Dinc, G., Sakar, A., et al., Prevalence and Comorbidity of Allergic Eczema, Rhinitis, and Asthma in a City of Western Turkey, J. Investing. Allergol. Clin. Immunol., 2008, vol. 18, pp. 31–35.Google Scholar
  15. 15.
    Gustaffson, G., Sjoberg, O., and Foucard, T, Development of Allergies and Asthma in Infants and Young Children with Atopic Dermatitis—a Prospective Follow-up to 7 Years of Age, Allergy, 2000, vol. 55, pp. 240–245.CrossRefGoogle Scholar
  16. 16.
    Freidin, M.B. and Puzyrev, V.P., Genomic Bases of Susceptibility to Atopic Diseases, Mol. Med., 2007, no. 3, pp. 26–35.Google Scholar
  17. 17.
    Shiina, T., Hosomichi, K., Inoko, H., and Kulski, J.K., The HLA Genomic Loci Map, Expression, Interaction, Diversity and Disease, J. Hum. Genet., 2009, vol. 54, pp. 15–39.CrossRefPubMedGoogle Scholar
  18. 18.
    Kuperman, D.A. and Schleimer, R.P., Interleukin-4, Interleukin-13, Signal Transducer and Activator of Transcription Factor 6, and Allergic Asthma, Curr. Mol. Med., 2008, vol. 8, pp. 384–392.CrossRefPubMedGoogle Scholar
  19. 19.
    Hershey, G.K.K., Friedrich, M.F., Esswein, L.A., et al., The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor, New Eng. J. Med., 1997, vol. 337, pp. 1720–1725.CrossRefPubMedGoogle Scholar
  20. 20.
    Mitsuyasu, H., Yanagihara, Y, Mao, X.-Q., et al., Dominant Effect of Ile50Val Variant of the Human IL-4 Receptor α-Chain in IgE Synthesis, J. Immunol., 1999, vol. 162, pp. 1227–1231.PubMedGoogle Scholar
  21. 21.
    Yamasaki, S. and Saito, T., Progress in Allergy Signal Research on Mast Cells, Signal Regulation of Multiple Mast Cell Responses through FcepsilonRI, J. Pharmacol. Sci., 2008, vol. 106, pp. 336–340.CrossRefPubMedGoogle Scholar
  22. 22.
    Sandford, A.J., Shirakawa, T., Moffatt, M.F., et al., Localization of Atopy and Beta Subunit of High-Affinity IgE Receptor (FCER1) on Chromosome 1 1q, Lancet, 1993, vol. 341, pp. 332–334.CrossRefPubMedGoogle Scholar
  23. 23.
    Penrose, J.F. and Baldasaro, M.H., Leukotriene C4 Synthase, a Candidate Gene for the Aspirin-Intolerant Asthmatic Phenotype, Allergy Asthma Proc., 1999, vol. 20, pp. 353–360.CrossRefPubMedGoogle Scholar
  24. 24.
    Palikhe, N.S., Kim, S.H., and Park, H.S., What Do We Know about the Genetics of Aspirin Intolerance?, J. Clin. Pharm. Ther., 2008, vol. 33, pp. 465–472.CrossRefPubMedGoogle Scholar
  25. 25.
    Smits, H.H. and Yazdanbakhsh, M., Chronic Helminth Infections Modulate Allergen-Specific Immune Responses: Protection against Development of Allergic Disorders?, Ann. Med., 2007, vol. 39, pp. 428–439.CrossRefPubMedGoogle Scholar
  26. 26.
    Pulleyn, L.J., Newton, R., Adcock, I.M., and Barnes, P.J., TGFbeta1 Allele Association with Asthma Severity, Hum. Genet., 2001, vol. 109, pp. 623–627.CrossRefPubMedGoogle Scholar
  27. 27.
    Meng, J., Thongngarm, T., Nakajima, M., et al., Association of Transforming Growth Factor-Beta 1 Single Nucleotide Polymorphism C-509T with Allergy and Immunological Activities, Int. Arch. Allergy Immunol., 2005, vol. 138, pp. 151–160.CrossRefPubMedGoogle Scholar
  28. 28.
    Qiao, H.L., Wen, Q., Gao, N, et al., Association of IL 10 Level and IL-10 Promoter SNPs with Specific Antibodies in Penicillin-Allergic Patients, Eur. J. Clin. Pharmacol., 2007, vol. 63, pp. 263–269.CrossRefPubMedGoogle Scholar
  29. 29.
    Kim, S.H., Yang, E.M., Lee, H.N., et al., Combined Effect of IL-10 and TGF-Betal Promoter Polymorphisms as a Risk Factor for Aspirin-Intolerant Asthma and Rhinosinusitis, Allergy, 2009, vol. 64, pp. 1221–1225.CrossRefPubMedGoogle Scholar
  30. 30.
    Cookson, W., The Immunogenetics of Asthma and Eczema, a New Focus on the Epithelium, Nat. Rev. Immunol., 2004, vol. 4, pp. 978–988.CrossRefPubMedGoogle Scholar
  31. 31.
    Novak, N., Peng, W., and Yu, C., Network of Myeloid and Plasmacytoid Dendritic Cells in Atopic Dermatitis, Adv. Exp. Med. Biol., 2007, vol. 601, pp. 97–104.PubMedGoogle Scholar
  32. 32.
    Eriksson, N.E., MÖller, C, Werner, S., et al., Self-Reported Food Hypersensitivity in Sweden, Denmark, Estonia, Lithuania, and Russia, J. Investig. Allergol. Clin. Immunol., 2004, vol. 14, pp. 70–79.PubMedGoogle Scholar
  33. 33.
    Colver, A.F., Nevantaus, H., Macdougall, C.F., and Cant, A.J., Severe Food-Allergic Reactions in Children across the UK and Ireland, 1998–2000, Acta Paediatr., 2005, vol. 94, pp. 689–695.CrossRefPubMedGoogle Scholar
  34. 34.
    Thong, B.Y.H., Cheng, YK., Leong, K.P., et al., Immediate Food Hypersensitivity among Adults Attending a Clinical Immunology/Allergy Centre in Singapore, Singapore Med. J., 2007, vol. 48, pp. 236–240.PubMedGoogle Scholar
  35. 35.
    The Wellcome Trust Case Control Consortium: Genome-Wide Association Study of 14000 Cases of Seven Common Diseases and 3000 Shared Controls, Nature, 2007, vol. 447, pp. 661–678.Google Scholar
  36. 36.
    Wellcome Trust Case Control Consortium and The Australo-Anglo-American Spondylitis Consortium: Association Scan of 14500 Nonsynonymous SNPs in Four Diseases Identifies Autoimmunity Variants, Nat. Genet., 2007, vol. 39, pp. 1329–1337.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Research Institute of Medical Genetics, Siberian BranchRussian Academy of Medical SciencesTomskRussia

Personalised recommendations