Russian Journal of Genetics

, Volume 45, Issue 7, pp 870–874 | Cite as

Analysis of the mitochondrial DNA diversity in Yukaghirs in the evolutionary context

  • N. V. Volodko
  • N. P. Eltsov
  • E. B. Starikovskaya
  • R. I. Sukernik
Human Genetics


Based on the mtDNA first hypervariable segment sequence variation data, statistical analysis of the diversity in Yukaghirs in comparison with the other indigenous populations of Siberia, was carried out. The level of the Yukaghir mtDNA gene diversity (GD) constituted 0.920, which was only slightly different from the corresponding estimate for the other Siberian populations. Integral estimates of the genetic structure of Siberian populations (k, S, θ S , and π) are presented. Phylogenetic analysis, performed using the neighbor-joining method, showed that the Siberian populations clustered irrespectively to their language affiliation. Negative F s values found in Yukaghirs pointed to the possible influence of adaptive selection.


Indigenous Population Integral Estimate Adaptive Selection Siberian Population Pairwise Nucleotide Difference 
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  1. 1.
    Simchenko, Yu.B., Kul’tura okhotnikov na olenei Severnoi Evrazii (The Culture of Deer Hunters in Northern Eurasia), Moscow: Nauka, 1976.Google Scholar
  2. 2.
    Okladnikov, A.P., Yakutiya do prisoedineniya k Russkomu gosudarstvu (Yakutia before Incorporation into the Russian State), Moscow, 1955.Google Scholar
  3. 3.
    Khlobystin, L.P., Drevnyaya istoriya Taimyrskogo zapolyar’ya i voprosy formirovaniya kul’tur severa Evrazii (Ancient History of Taimyr Transpolar and the Culture Forming in the North of Eurasia), St. Petersburg: Dmitrii Bulanin, 1998.Google Scholar
  4. 4.
    Dolgikh, B., Tribal Content of Siberian Population in the 17th Century, Trudy Instituta Etnografii AN SSSR, 1960, vol. 55, pp. 3–623.Google Scholar
  5. 5.
    D’yachkov, A., Anadyrskii krai: Rukopis’ zhitelya sela Markovo (Anadyr Kray: The Manuscript of Inhabitant of Markovo Settlement), Vladivostok, 1893.Google Scholar
  6. 6.
    Johelson, W., The Yukaghir and the Yukaghirized Tungus: The Jesup North Pacific Expedition, New York, 1910, vols. I–III.Google Scholar
  7. 7.
    Spiridonov, N.I., Oduly (yukagiry) Kolymskogo okruga (Oduls (Yukaghirs) of Kolyma District), Yakutsk: Severoved, 1935.Google Scholar
  8. 8.
    Tugolukov, V.A., Kto vy, yukagiry? (Who Are You, Yukaghirs?), Moscow: Nauka, 1979.Google Scholar
  9. 9.
    Volodko, N.V., Starikovskaya, Y.B., Mazunin, I.O., et al., Mitochondrial Genome Diversity in Arctic Siberians, with Particular Reference to the Evolutionary History of Beringia and Pleistocenic Peopling of the Americas, Am. J. Hum. Genet., 2008, vol. 82, pp. 1084–1100.PubMedCrossRefGoogle Scholar
  10. 10.
    Torroni, A., Sukernik, R.I., Schurr, T.G., et al., mtDNA Variation of Aboriginal Siberians Reveals Distinct Genetic Affinities with Native Americans, Am. J. Hum. Genet., 1993, vol. 53, pp. 591–608.PubMedGoogle Scholar
  11. 11.
    Pakendorf, B., Novgorodov, I.N., Osakovskij, V.L., et al., Investigating the Effects of Prehistoric Migrations in Siberia: Genetic Variation and the Origins of Yakuts, Hum. Genet., 2006, vol. 120, pp. 334–353.PubMedCrossRefGoogle Scholar
  12. 12.
    Nei, M., Molecular Evolutionary Genetics, New York: Columbia Univ. Press, 1987.Google Scholar
  13. 13.
    Tajima, F., Statistical Method for Testing the Neutral Mutation Hypothesis by DNA Polymorphism, Genetics, 1989, vol. 123, pp. 585–595.PubMedGoogle Scholar
  14. 14.
    Fu, Y.X., Statistical Tests of Neutrality of Mutations against Population Growth, Hitchhiking and Background Selection, Genetics, 1997, vol. 147, pp. 915–925.PubMedGoogle Scholar
  15. 15.
    Schneider, S., Roessli, D., and Excoffier, L., ARLEQUIN, Version 2.000: A Software for Population Genetics Data Analysis, Geneva: Univ. Geneva, 2000.Google Scholar
  16. 16.
    Takezaki, N. and Nei, M., Genetic Distances and Reconstruction of Phylogenetic Trees from Microsatellite DNA, Genetics, 1996, vol. 144, pp. 389–399.PubMedGoogle Scholar
  17. 17.
    Saitou, N. and Nei, M., The Neighbor-Joining Method: A New Method for Reconstructing Phylogenetic Trees, Mol. Biol. Evol., 1987, vol. 4, pp. 406–425.PubMedGoogle Scholar
  18. 18.
    Takezaki N. NJBAFD: Neighbor-Joining Tree Constructions from Allele Frequency Data,
  19. 19.
    Starikovskaya, E.B., Sukernik, R.I., Derbeneva, O.A., et al., Mitochondrial DNA Diversity in Indigenous Populations of the Southern Extent of Siberia, and the Origins of Native American Haplogroups, Ann. Hum. Genet., 2005, vol. 69, pp. 67–89.PubMedCrossRefGoogle Scholar
  20. 20.
    Watterson, G.A., On the Number of Segregating Sites in Genetical Models without Recombination, Theor. Popul. Biol., 1975, vol. 7, pp. 256–276.PubMedCrossRefGoogle Scholar
  21. 21.
    Mishmar, D., Ruiz-Pesini, E., Golik, P., et al., Natural Selection Shaped Regional mtDNA Variation in Humans, Proc. Natl. Acad. Sci. USA, 2003, vol. 100, pp. 171–176.PubMedCrossRefGoogle Scholar
  22. 22.
    Elson, J.L., Turnbull, D.M., and Howell, N., Comparative Genomics and the Evolution of Human Mitochondrial DNA: Assessing the Effects of Selection, Am. J. Hum. Genet., 2004, vol. 74, pp. 229–238.PubMedCrossRefGoogle Scholar
  23. 23.
    Ruiz-Pesini, E., Mishmar, D., Brandon, M., et al., Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNA, Science, 2004, vol. 303, pp. 223–226.PubMedCrossRefGoogle Scholar
  24. 24.
    Elson, J.L., Turnbull, D.M., and Taylor, R.W., Testing the Adaptive Selection of Human mtDNA Haplogroups: An Experimental Bioenergetics Approach, Biochem. J., 2007, vol. 404, pp. e3–e5.PubMedCrossRefGoogle Scholar
  25. 25.
    Nielsen, R., Molecular Signatures of Natural Selection, Ann. Rev. Genet., 2005, vol. 39, pp. 197–218.PubMedCrossRefGoogle Scholar
  26. 26.
    Volodko, N.V., Eltsov, N.P., Naidenko, P.V., et al., Selection Left Distinctive Signatures at the Human Mitochondrial Genome Level in Siberia/Beringia, 20th International Congress of Genetics: Abstracts, Berlin, 2008, p. 152.Google Scholar
  27. 27.
    Derbeneva, O.A., Starikovskaya, E.B., Volodko, N.V., et al., Mitochondrial DNA Variation in the Kets and Nganasans and Its Implications for the Initial Peopling of Northern Eurasia, Russ. J. Genet., 2002, vol. 38, no. 11, pp. 1316–1321.CrossRefGoogle Scholar
  28. 28.
    Derbeneva, O.A., Starikovskaya, E.B., Wallace, D.C., and Sukernik, R.I., Traces of Early Eurasians in the Mansi of Northwest Siberia Revealed by Mitochondrial DNA Analysis, Am. J. Hum. Genet., 2002, vol. 70, pp. 1009–1014.PubMedCrossRefGoogle Scholar
  29. 29.
    Derenko, M.V. and Shilds, D.F., Nucleotide Sequence Diversity of Mitochondrial DNA in Three Groups of the North Asian Indigenous Populations, Mol. Biol., (Moscow), 1997, vol. 31, pp. 784–789.Google Scholar
  30. 30.
    Schurr, T.G., Sukernik, R.I., Starikovskaya, Y.B., and Wallace, D.C., Mitochondrial DNA Variation in Koryaks and Itel’men: Population Replacement in the Okhotsk Sea-Bering Sea Region during the Neolithic, Am. J. Phys. Anthropol., 1999, vol. 108, pp. 1–39.PubMedCrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  • N. V. Volodko
    • 1
  • N. P. Eltsov
    • 1
  • E. B. Starikovskaya
    • 1
  • R. I. Sukernik
    • 1
  1. 1.Institute of Cytology and GeneticsRussian Academy of SciencesNovosibirskRussia

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