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Russian Journal of Genetics

, Volume 45, Issue 5, pp 605–612 | Cite as

Polymorphism of the prion protein gene PRNP and risk of multiple sclerosis development in ethnic Russians from Bashkortostan

  • O. V. Chubukova
  • O. E. Mustafina
  • A. V. Chemeris
  • I. A. Tuktarova
  • K. Z. Bahtijarova
  • R. V. Magjanov
  • Yu. M. Nikonorov
Human Genetics

Abstract

M129V polymorphism of prion protein gene PRNP has been studied in patients with multiple sclerosis (MS) and healthy ethnic Russians from Bashkortostan using allele-specific PCR. The genotype frequency distribution of the examined polymorphism in Russians from Bashkortostan was similar to that in European populations. MM, MV, and VV genotype frequencies in control group and in the MS patients were 50.24%, 42.58%, 7.18% and 43.33%, 45.83%, 10.84%, respectively. It was shown that in the group of MS patients with onset of the disease at the age of 21 and older, the frequency of the VV genotype was higher than in the control group (14.3% versus 6.18%, respectively, P = 0.041). We suggest that the VV genotype is associated with higher risk factor of MS development in the patients aged 21 years and older.

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Prion Protein Prion Disease PRNP Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  • O. V. Chubukova
    • 1
  • O. E. Mustafina
    • 1
  • A. V. Chemeris
    • 1
  • I. A. Tuktarova
    • 1
  • K. Z. Bahtijarova
    • 1
  • R. V. Magjanov
    • 2
  • Yu. M. Nikonorov
    • 1
  1. 1.Institute of Biochemistry and Genetics, Ufa Research CenterRussian Academy of SciencesUfaRussia
  2. 2.Bashkir State Medical UniversityUfaRussia

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