Russian Journal of Genetics

, Volume 45, Issue 3, pp 287–291 | Cite as

Conservative E(y)2/Sus1 protein interacts with the Su(Hw)-dependent insulators in Drosophila

  • M. M. Kurshakova
  • D. V. Kopytova
  • E. N. Nabirochkina
  • N. V. Soshnikova
  • S. G. Georgieva
  • A. N. Krasnov
Molecular Genetics


Insulators are regulatory elements having two properties. First, they are able to disturb the interaction between promoters and enhancers/silencers. Second, they are able to block distribution of the heterochromatin. The best-studied are the Su(Hw)-dependent insulators of Drosophila melanogaster, activity of which is determined by the Su(Hw) protein. In this study it was demonstrated that novel, evolutionary conservative transcription factor E(y)2/Sus1 interacted with the Su(Hw) zinc-finger domain and was present in the protein complex, associated with the Su(Hw)-dependent insulators.


Acid Domain Flag Epitope Gypsy Insulator Chromatin Template Insulator Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  • M. M. Kurshakova
    • 1
  • D. V. Kopytova
    • 1
  • E. N. Nabirochkina
    • 1
    • 2
  • N. V. Soshnikova
    • 1
  • S. G. Georgieva
    • 1
    • 2
    • 3
  • A. N. Krasnov
    • 1
    • 2
  1. 1.Institute of Gene BiologyRussian Academy of SciencesMoscowRussia
  2. 2.University of Oslo Center for Medical Studies, RussiaMoscowRussia
  3. 3.Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia

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