Abstract
In plants, Rab proteins represent the largest family of monomeric GTP-binding proteins (mG-proteins). As distinct from animal cells comprising 40 subfamilies of Rab proteins, which are the key regulators of intracellular vesicular transport, numerous Rab proteins in Arabidopsis and other plant species could be grouped in only eight subfamilies on the basis of their functional properties. The available data concerning the involvement of these mG-proteins in the control of vesicle trafficking agree generally with the paradigms accepted for other eukaryotes. On the other hand, these proteins play an important role in plant responses to abiotic and biotic factors, indicating specific for plants functions of Rab proteins.
Similar content being viewed by others
Abbreviations
- AG:
-
Golgi apparatus
- CA:
-
constitutively active
- DN:
-
dominant negative
- ER:
-
endoplasmic reticulum
- GAP:
-
GTPase-activating protein
- GDI:
-
guanine nucleotide dissociation inhibitor
- GEP:
-
guanine nucleotide exchange protein
- GFP:
-
green fluorescent protein
- mG-proteins:
-
monomeric GTP-binding proteins
- PM:
-
plasma membrane
- RFP:
-
red fluorescent protein
References
The Arabidopsis Genome Initiative. Analysis of the Genome Sequence of the Flowering Plant Arabidopsis thaliana, Nature, 2000, vol. 408, pp. 796–815.
Novick, P., Field, C., and Schekman, R., Identification of 23 Complementation Groups Required for Posttranslational Events in the Yeast Secretory Pathway, Cell, 1980, vol. 21, pp. 205–215.
Salminen, A. and Novick, P.J., A Ras-Like Protein Is Required for a Post-Golgi Event in Yeast Secretion, Cell, 1987, vol. 49, pp. 527–538.
Lazar, T., Gotte, M., and Gallwitz, D., Vesicular Transport: How Many Ypt/Rab-GTPases Make a Eukaryotic Cell? Trends Biochem. Sci., 1997, vol. 22, pp. 468–472.
Segev, N., Ypt and Rab GTPases: Insight into Functions through Novel Interactions, Curr. Opin. Cell Biol., 2001, vol. 13, pp. 500–511.
Zerial, M. and McBride, H., Rab Proteins as Membrane Organizers, Nat. Rev. Mol. Cell Biol., 2001, vol. 2, pp. 107–117.
Takai, Y., Sasaki, T., and Matozaki, T., Small GTP-Binding Proteins, Physiol. Rev., 2001, vol. 81, pp. 153–208.
Ueda, T., Yoshizumi, T., Anai, T., Matsui, M., Uchimiya, H., and Nakano, A., AtGDI2, a Novel Arabidopsis Gene Encoding a Rab GDP Dissociation Inhibitor, Gene, 1998, vol. 206, pp. 137–143.
Fukuda, M., Distinct Rab Binding Specificity of Rim1, Rim2, Rabphilin, and Noc2. Identification of a Critical Determinants of Rab3A/Rab27A Recognition by Rim2, J. Biol. Chem., 2003, vol. 278, pp. 15373–15380.
Jensen, R.B., la Cour, T., Albrethsen, J., Nielsen, M., and Skriver, K., FYVE Zinc-Finger Proteins in the Plant Model Arabidopsis thaliana: Identification of PtdIns3P-Binding Residues by Comparison of Classic and Variant FYVE Domains, Biochem. J., 2001, vol. 1, pp. 165–173.
Heras, B. and Drobak, B.K., PARF-1: An Arabidopsis thaliana FYVE-Domain Protein Displaying a Novel Eukaryotic Domain Structure and Phosphoinositide Affinity, J. Exp. Bot., 2002, vol. 53, pp. 565–567.
Pereira-Leal, J.B. and Seabra, M.C., The Mammalian Rab Family of Small GTPases: Definition of Family and Subfamily Sequence Motifs Suggests a Mechanism for Functional Specificity in the Ras Superfamily, J. Mol. Biol., 2000, vol. 301, pp. 1077–1087.
Pereira-Leal, J.B. and Seabra, M.C., Evolution of the Rab Family of Small GTP-Binding Proteins, J. Mol. Biol., 2001, vol. 313, pp. 889–901.
Vernoud, V., Horton, A.C., Yang, Z., and Nielsen, E., Analysis of the Small GTPase Gene Superfamily of Arabidopsis, Plant Physiol., 2003, vol. 131, pp. 1191–1208.
Schlierf, B., Fey, G.H., Hauber, J., Hocke, G.M., and Rosorius, O., Rab11b Is Essential for Recycling of Transferrin to the Plasma Membrane, Exp. Cell Res., 2000, vol. 259, pp. 257–265.
Volpicelli, L.A., Lah, J.J., Fang, G., Goldenring, J.R., and Levey, A.I., Rab11a and Myosin Vb Regulate Recycling of the M4 Muscarinic Acetylcholine Receptor, J. Neurosci., 2002, vol. 15, pp. 9776–9784.
Inaba, T., Nagano, Y., Nagasaki, T., and Sasaki, Y., Distinct Localization of Two Closely Related Ypt3/Rab11 Proteins on the Trafficking Pathway in Higher Plants, J. Biol. Chem., 2002, vol. 277, pp. 9183–9188.
Kang, J.G., Yun, J., Kim, D.H., Chung, K.S., Fujioka, S., Kim, J.I., Dae, H.W., Yoshida, S., Takatsuto, S., Song, P.S., and Park, C.M., Light and Brassinosteroid Signals Are Integrated via a Dark-Induced Small G Protein in Etiolated Seedling Growth, Cell, 2001, vol. 105, pp. 625–636.
Ueda, T., Anai, T., Tsukaya, H., Hirata, A., and Uchimiya, H., Characterization and Subcellular Localization of a Small GTP Binding Protein (Ara-4) from Arabidopsis: Conditional Expression under Control of the Promoter of the Gene for Heat-Shock Protein HSP81-1, Mol. Gen. Genet., 1996, vol. 250, pp. 533–539.
Preuss, M.L., Serna, J., Falbel, T.G., Bednarek, S.Y., and Nielsen, E., The Arabidopsis Rab GTPase RabA4b Localizes to the Tips of Growing Root Hair Cells, Plant Cell, 2004, vol. 16, pp. 1589–1603.
Ueda, T., Matsuda, N., Uchimiya, H., and Nakano, A., Modes of Interaction between the Arabidopsis Rab Protein, Ara4, and Its Putative Regulator Molecules Revealed by a Yeast Expression System, Plant J., 2000, vol. 21, pp. 341–349.
Zainal, Z., Tucker, G.A., and Lycett, G.W., A rab11-Like Gene Is Developmentally Regulated in Ripening Mango (Mangifera indica L.) Fruit, Biochim. Biophys. Acta, 1996, vol. 1314, pp. 187–190.
Lu, C., Zainal, Z., Tucker, G.A., and Lycett, G.W., Developmental Abnormalities and Reduced Fruit Softening in Tomato Plants Expressing an Antisense Rab11 GTPase Gene, Plant Cell, 2001, vol. 13, pp. 1819–1833.
Marin-Rodriguez, M.C., Orchard, J., and Seymour, G.B., Pectate Lyases, Cell Wall Degradation and Fruit Softening, J. Exp. Bot., 2002, vol. 53, pp. 2115–2119.
Seymour, G.B., Manning, K., Eriksson, E.M., Popovich, A.H., and King, G.J., Genetic Identification and Genomic Organization of Factors Affecting Fruit Texture, J. Exp. Bot., 2002, vol. 53, pp. 2065–2071.
Short, B., Preisinger, C., Korner, R., Kopajtich, R., Byron, O., and Barr, F.A., A GRASP55-Rab2 Effector Complex Linking Golgi Structure to Membrane Traffic, J. Cell Biol., 2001, vol. 155, pp. 877–883.
Nebenführ, A. and Staehelin, L.A., Mobile Factories: Golgi Dynamics in Plant Cells, Trends Plant Sci., 2001, vol. 6, pp. 160–167.
Boevink, P., Oparka, K., Cruz, S.S., Martin, B., Betteridge, A., and Hawes, C., Stacks on Tracks: The Plant Golgi Apparatus Traffics on an Actin/ER Network, Plant J., 1998, vol. 15, pp. 441–447.
Crofts, A.J., Leborgne-Castel, N., Hillmer, S., Robinson, D.G., Phillipson, B., Carlsson, L.E., Ashford, D.A., and Denecke, J., Saturation of the Endoplasmic Reticulum Retention Machinery Reveals Anterograde Bulk Flow, Plant Cell, 1999, vol. 11, pp. 2233–2247.
Boevink, P., Martin, B., Oparka, K., Cruz, S.S., and Hawes, C., Transport of Virally Expressed Green Fluorescent Protein through the Secretory Pathway in Tobacco Leaves Is Inhibited by Cold Shock and Brefeldin A, Planta, 1999, vol. 208, pp. 392–400.
Cheung, A.Y., Chen, C.Y.H., Glaven, R.H., de Graaf, B.H.J., Vidali, L., Hepler, P.K., and Wu, H.M., Rab2 GTPase Regulates Vesicle Trafficking between the Endoplasmic Reticulum and the Golgi Bodies and Is Important to Pollen Tube Growth, Plant Cell, 2002, vol. 14, pp. 945–962.
Batoko, H., Zheng, H.Q., Hawes, C., and Moore, I., A Rab1 GTPase Is Required for Transport between the Endoplasmic Reticulum and Golgi Apparatus and for Normal Golgi Movement in Plants, Plant Cell, 2000, vol. 12, pp. 2201–2217.
Saint-Jore, C.M., Evins, J., Batoko, H., Brandizzi, F., Moore, I., and Hawes, C., Redistribution of Membrane Proteins between the Golgi Apparatus and Endoplasmic Reticulum in Plants Is Reversible and Not Dependent on Cytoskeletal Networks, Plant J., 2002, vol. 29, pp. 661–678.
Bogdanove, A.J. and Martin, G.B., AvrPto-Dependent Pto-Interacting Proteins and AvrPto-Interacting Proteins in Tomato, Proc. Natl. Acad. Sci. USA, 2000, vol. 97, pp. 8836–8840.
Moshkov, I.E., Mur, L.A.J., Novikova, G.V., Smith, A.R., and Hall, M.A., Ethylene Regulates Monomeric GTPBinding Protein Gene Expression and Activity in Arabidopsis thaliana, Plant Physiol., 2003, vol. 131, pp. 1705–1717.
Moshkov, I.E., Novikova, G.V., Mur, L.A.J., Smith, A.R., and Hall, M.A., Ethylene Rapidly Upregulates the Activities of Both Monomeric GTP-Binding Proteins and Protein Kinase(s) in Epicotyls of Pisum sativum L., Plant Physiol., 2003, vol. 131, pp. 1718–1726.
Chen, Y.-F., Randlett, M.D., Findell, J.L., and Schaller, G.E., Localization of the Ethylene Receptor ETR1 to the Endoplasmic Reticulum of Arabidopsis, J. Biol. Chem., 2002, vol. 277, pp. 19 861–19 866.
Zheng, H., Camacho, L., Wee, E., Batoko, H., Legen, J., Leaver, C.J., Malho, R., Hussey, P.J., and Moore, I., A Rab-E GTPase Mutant Acts Downstream of the Rab-D Subclass in Biosynthetic Membrane Traffic to the Plasma Membrane in Tobacco Leaf Epidermis, Plant Cell, 2005, vol. 17, pp. 2020–2036.
Holstein, S.E.M., Clathrin and Plant Endocytosis, Traffic, 2002, vol. 3, pp. 614–620.
Ueda, T., Yamaguchi, M., Uchimiya, H., and Nakano, A., Ara6, a Plant-Unique Novel Type Rab GTPase, Functions in the Endocytic Pathway of Arabidopsis thaliana, EMBO J., 2001, vol. 20, pp. 4730–4741.
Borg, S., Brandstrup, B., Jensen, T.J., and Poulsen, C., Identification of New Protein Species among 33 Different Small GTP-Binding Proteins Encoded by cDNAs from Lotus japonicus, and Expression of Corresponding mRNAs in Developing Root Nodules, Plant J., 1997, vol. 11, pp. 237–250.
Bolte, S., Schiene, K., and Dietz, K.J., Characterization of a Small GTP-Binding Protein of the Rab 5 Family in Mesembryanthemum crystallinum with Increased Level of Expression during Early Salt Stress, Plant Mol. Biol., 2000, vol. 42, pp. 923–936.
Bucci, C., Parton, R.G., Mather, I.H., Stunnenberg, H., Simons, K., Hoflack, B., and Zerial, M., The Small GTPase Rab5 Functions as a Regulatory Factor in the Early Endocytic Pathway, Cell, 1992, vol. 70, pp. 715–728.
Ueda, T., Uemura, T., Sato, M.H., and Nakano, A., Functional Differentiation of Endosomes in Arabidopsis Cells, Plant J., 2004, vol. 40, pp. 783–789.
Cheon, C., Lee, N., Siddique, A., Bal, A., and Verma, D., Roles of Plant Homologs of Rab1p and Rab7p in the Biogenesis of the Peribacteroid Membrane, a Subcellular Compartment Formed De Novo during Root Nodule Symbiosis, EMBO J., 1993, vol. 12, pp. 4125–4135.
Mazel, A., Leshem, Y., Tiwari, B.S., and Levine, A., Induction of Salt and Osmotic Stress Tolerance by Over-expression of an Intracellular Vesicle Trafficking Protein AtRab7 (AtRabG3e), Plant Physiol., 2004, vol. 134, pp. 118–128.
Nahm, M.Y., Kim, S.W., Yun, D., Lee, S.Y., Cho, M.J., and Bahk, J.D., Molecular and Biochemical Analyses of OsRab7, a Rice Rab7 Homolog, Plant Cell Physiol., 2003, vol. 44, pp. 1341–1349.
Kirchhausen, T., Three Ways to Make a Vesicle, Nat. Rev. Mol. Cell Biol., 2000, vol. 1, pp. 187–198.
White, J., Johannes, L., Mallard, F., Girod, A., Grill, S., Reinsch, S., Keller, P., Tzschaschel, B., Echard, A., Goud, B., and Stelzer, E.H.K., Rab6 Coordinates a Novel Golgi to ER Retrograde Transport Pathway in Live Cells, J. Cell Biol., 1999, vol. 147, pp. 743–759.
Storrie, B., Pepperkok, R., and Nilsson, T., Breaking the COPI Monopoly on Golgi Recycling, Trends Cell Biol., 2000, vol. 10, pp. 385–391.
Robinson, D.G., Rogers, J.C., and Hinz, G., Post-Golgi, Pre-Vacuolar Compartments, Annu. Plant Rev., 2000, vol. 5, pp. 270–298.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © I.E. Moshkov, G.V. Novikova, 2008, published in Fiziologiya Rastenii, 2008, Vol. 55, No. 1, pp. 127–139.
Rights and permissions
About this article
Cite this article
Moshkov, I.E., Novikova, G.V. Superfamily of plant monomeric GTP-binding proteins: 2. Rab proteins are the regulators of vesicles trafficking and plant responses to stresses. Russ J Plant Physiol 55, 119–129 (2008). https://doi.org/10.1134/S1021443708010159
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1021443708010159