The Influence of Leukocytes on the Activity of Cardiovascular System in Women with High Blood Pressure

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Thirty apparently healthy elderly women and 72 women diagnosed with Hypertensive Heart Disease (HHD) participated in the study. The subjects with hypertension were divided into two groups: the first group (HHD-1) included women receiving medication; the second group (HHD-2) included women receiving medication and kinesiotherapy (three or four courses regularly during the past two to three years). In elderly women with a high blood pressure, the total number of lymphocytes and eosinophils was higher than in healthy women. The women with hypertension also had higher values of stroke volume (SV), left ventricular end diastolic volume (LVEDV), cardiac output (CO), left ventricular mass (LVDM), and left ventricular mass index (LVMI). In women with hypertension, the balance of velocity distribution in the arteries and microvasculature was shifted toward the fast interlayer processes. In women who exercised regularly, these changes were much smaller. In both healthy women and women with hypertension, there was an association between the total leukocyte count, individual types of leukocytes, the level of blood pressure, and hemodynamic parameters. The strongest relationships were observed between the number of eosinophils and the blood pressure.

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The authors are grateful to the staff members and, especially, to Irina Anatolievna Dneprovskaya, the head of the clinical laboratory of the Akademia Zdorovia Innovation clinics, for carrying out laboratory tests.


The study was performed without supplementary fundin-g.

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Correspondence to B. I. Kuznik.

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Conflict of interest. The authors declare that they have no obvious or potential conflict of interest related to the publication of this article.

Statement of compliance with standards of research involving humans as subjects. The experiments were performed in accordance with the statement of ethical principles for biomedical research of the Declaration of Helsinki 1964 and its subsequent updates and were approved by the local Biomedical Ethical Committee of the Chita State Medical Academy (Chita). Each participant signed a voluntary written informed consent after the explanation of the potential risks and benefits of participation in the study and its specificity.

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Translated by I. Matiulko

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Kuznik, B.I., Davydov, S.O., Guseva, E.S. et al. The Influence of Leukocytes on the Activity of Cardiovascular System in Women with High Blood Pressure. Hum Physiol 45, 649–657 (2019).

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  • leukocytes
  • neutrophils
  • lymphocytes
  • monocytes
  • eosinophils
  • cardiodynamics
  • hemodynamics
  • hypertension
  • moderate exercise