The parameters of phosphorus–calcium metabolism at different levels of 25 (OH)D in young people have been studied. The studied population included 48 young men and 126 young women aged 18 to 20 years. Normal values of vitamin D were found in 40 subjects (23%); the blood level of 25-OH vitamin D was shown to be 20–30 ng/mL in 59 subjects (34%), 10–19 ng/mL in 56 subjects (32%), and <10 ng/mL in 19 subjects (11%). The calcium level proved to be associated with the rate of vitamin D deficiency. The level of parathyroid hormone was not elevated in 75% of the subjects with vitamin D deficiency. There is no correlation between PTH levels and vitamin D levels. The results show the necessity of further studies to find out the causes of insufficient response of parathyroid hormone to vitamin D deficiency.
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We are grateful to researchers of the Central Research Laboratory of the Northern State Medical University (Arkhangelsk).
The study was supported by the Northern State Medical University (Arkhangelsk).
Conflict of interests. The authors declare that they have no conflict of interest.
Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the Northern State Medical University (Arkhangelsk), Protocol no. 04/01-16 of February 3, 2016, and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.
Translated by E. V. Makeeva
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Malyavskaya, S.I., Kostrova, G.N., Strelkova, A.V. et al. Evaluation of Phosphorus–Calcium Homeostasis Parameters in Young People with Various Serum Levels of 25(OH)D Living in the Arctic Region. Hum Physiol 45, 679–684 (2019) doi:10.1134/S0362119719040108
- vitamin D
- parathyroid hormone