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Human Physiology

, Volume 45, Issue 1, pp 90–97 | Cite as

The Correlation between the Pool of Free Adhesion Molecule Receptors and the Activity of the Immune System in the Murmansk Oblast Residents

  • A. V. SamodovaEmail author
  • L. K. Dobrodeeva
Article

Abstract

The molecules of intercellular adhesion are the surface cellular glycoproteins responsible for interaction between cells of different types with one another and with the components of intercellular matrix. They play the primary role in the formation of tissue structure and participate in a number of physiological processes, such as morphogenesis, embryogenesis, organogenesis, wound healing, and inflammation. Together with the other free receptors and their ligands, free intercellular adhesion molecules are formed mainly through shedding, resulting from the proteolytic cleavage of the transmembrane region under physiological conditions or cell destruction. There are almost no literature data on the influence of free intercellular adhesion molecules on the functional activity of T and B lymphocytes and the contents of immunoglobulins, cytokines, and circulating immune complexes. Therefore, the purpose of this study was to identify the interrelationship between the content of free and membrane-bound intercellular adhesion molecules and the level of immunocompetent cell activity in the residents of the Arctic settlement of Revda (Murmansk oblast), who form one of special populations of residents living in the Arctic region of the Russian Federation. It has been found that the contents of sCD54, sCD62L, and sCD324 free intercellular adhesion molecules vary widely, which results from an increase in the concentration of cells with the corresponding membrane forms. An increase in the levels of sCD54 and sCD62 is accompanied by the activation of migration processes with increasing concentrations of circulating neutrophils and total lymphocyte count. The formation of a pool of membrane-bound and free adhesion molecules occurs together with an increase in the content of activated T cells of the HLADRII and CD8 + phenotypes. An increase in the serum levels of sCD54 and L-selectin (sCD62L) adhesion molecules is accompanied by a decrease in the level of immunocompetent cell activity and a twofold increase in the serum level of a natural immunosuppressant IL-10. Low activity of the sCD54 and sCD62L is associated with an increase in the IgE concentration and in immune responses caused by the basophil and eosinophil activation.

Keywords:

free and membrane-bound intercellular adhesion molecules sCD54 sCD62L sCD324 neutrophils lymphocytes activated T-lymphocytes cytotoxic T-lymphocytes IL-10 IgE 

Notes

ACKNOWLEDGMENTS

The study was performed in the framework of the Programme for Basic Research on the following topics: “The Ratio between the Membrane and Extracellular Forms of Differential Molecules in Regulation of the Systemic Immune Response” (project no. 0409-2014-0216); project coordinator, Professor L.K. Dob-rodeeva, DSc; “The role of the extracellular pool of adhesion molecules and short peptides in the development and outcome of adaptive reactions” (project no. 0409-2016-0013); project coordinator, A.V. Samodova, PhD, of the laboratory of regulatory mechanisms of the immune system of the Institute of Physiology of Natural Adaptations.

COMPLIANCE WITH ETHICAL STANDARDS

Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. Before entering the study, the participants gave written informed consent. The study was performed in accordance with the World Medical Association Declaration of Helsinki on Ethical Principles for Medical Research (2000).

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Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  1. 1.Laverov Institute of Physiology of Natural Adaptations, Federal Research Center for Integrated Study of the Arctic, Russian Academy of SciencesArkhangelskRussia

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