The Ala/Val Polymorphism of the UCP2 Gene Is Reciprocally Associated with Aerobic and Anaerobic Performance in Athletes
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Associations between the C/T polymorphism of the UCP2 gene (AlaVal55, rs660339) and aerobic and anaerobic components of physical fitness of athletes were studied. The study involved 168 athletes (46 women and 122 men) engaged in various sports and 98 nonathletes (35 women and 63 men). The athletic performance testing program included the ramp test on a treadmill and the Wingate anaerobic test on a bicycle ergometer. The group of athletes exhibited a tendency towards a higher frequency of carriers of two alleles of “mitochondrial efficiency” (UCP2*TT) (χ2 = 2.53, p = 0.28). Val55 allele associations (T*UCP2) with higher values of functional indicators characterizing the aerobic abilities of athletes were demonstrated, whereas athletes carrying two original Ala55 alleles (UCP2*CC) had better anaerobic abilities.
Keywords:AlaVal55 polymorphism UCP2 physical capacities maximum oxygen consumption (VO2max) athletes selection
- 4.Flouris, A.D., Shidlovskii, Y.V., Shaposhnikov, A.V., et al., Role of UCP1 gene variants in interethnic differences in the development of cardio-metabolic diseases, Front. Genet., 2017, vol. 8, no. 7.Google Scholar
- 10.Bondareva, E.A., Parfenteva, O.I., and Son’kin, V.D., “Lean” genotype: obesity or athletic success? Vestn. Mosk. Univ., Ser. 23: Antropol., 2017, no. 3, p. 56.Google Scholar
- 14.Schrauwen, P. and Hesselink, M., UCP2 and UCP3 in muscle controlling body metabolism, J. Exp. Biol., 2002, vol. 205, p. 2275.Google Scholar
- 17.Holdys, J., Gronek, P., Kryściak, J., and Stanis-ławsk, D., Genetic variants of uncoupling proteins-2 and -3 in relation to maximal oxygen uptake in different sports, Acta Biochim. Pol., 2013, vol. 60, no. 1, p. 71.Google Scholar