Human Physiology

, Volume 44, Issue 6, pp 673–678 | Cite as

The Ala/Val Polymorphism of the UCP2 Gene Is Reciprocally Associated with Aerobic and Anaerobic Performance in Athletes

  • E. A. Bondareva
  • O. I. Parfenteva
  • A. V. Kozlov
  • U. S. Zhuravleva
  • E. V. Kosyakova
  • E. E. Karelina
  • E. S. Ketlerova
  • V. D. Son’kinEmail author


Associations between the C/T polymorphism of the UCP2 gene (AlaVal55, rs660339) and aerobic and anaerobic components of physical fitness of athletes were studied. The study involved 168 athletes (46 women and 122 men) engaged in various sports and 98 nonathletes (35 women and 63 men). The athletic performance testing program included the ramp test on a treadmill and the Wingate anaerobic test on a bicycle ergometer. The group of athletes exhibited a tendency towards a higher frequency of carriers of two alleles of “mitochondrial efficiency” (UCP2*TT) (χ2 = 2.53, p = 0.28). Val55 allele associations (T*UCP2) with higher values of functional indicators characterizing the aerobic abilities of athletes were demonstrated, whereas athletes carrying two original Ala55 alleles (UCP2*CC) had better anaerobic abilities.


AlaVal55 polymorphism UCP2 physical capacities maximum oxygen consumption (VO2max) athletes selection 



  1. 1.
    Toda, C. and Diano, S., Mitochondrial UCP2 in the central regulation of metabolism, Best Pract. Res., Clin. Endocrinol. Metab., 2014, vol. 28, no. 5, p. 757.CrossRefGoogle Scholar
  2. 2.
    Victorino, V., Mencalha, A., and Panis, C., Post-translational modifications disclose a dual role for redox stress in cardiovascular pathophysiology, Life Sci., 2015, vol. 129, p. 42.CrossRefGoogle Scholar
  3. 3.
    Cardoso, S., Correia, S., Carvalho, C., et al., Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection, J. Bioenerg. Biomembr., 2014, vol. 47, nos. 1–2, p. 119.CrossRefGoogle Scholar
  4. 4.
    Flouris, A.D., Shidlovskii, Y.V., Shaposhnikov, A.V., et al., Role of UCP1 gene variants in interethnic differences in the development of cardio-metabolic diseases, Front. Genet., 2017, vol. 8, no. 7.Google Scholar
  5. 5.
    Solanes, G., Vidal-Puig, A., Grujic, D., et al., The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts, J. Biol. Chem., 1997, vol. 272, p. 25433.CrossRefGoogle Scholar
  6. 6.
    Bouillaud, F., Alves-Guerra, M.C., and Ricquier, D., UCPs, at the interface between bioenergetics and metabolism, Biochim. Biophys. Acta, 2016, vol. 1863, p. 2443.CrossRefGoogle Scholar
  7. 7.
    Astrup, A., Toubro, S., Dalgaard, L.T., et al., Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation, Int. J. Obes. Relat. Metab. Disord., 1999, vol. 23, no. 10, p. 1030.CrossRefGoogle Scholar
  8. 8.
    Buemann, B., Schierning, B., Toubro, S., et al., The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency, Int. J. Obes. Relat. Metab. Disord., 2001, vol. 25, no. 4, p. 467.CrossRefGoogle Scholar
  9. 9.
    Bondareva, E.A., Andreev, R.S., Yakushkin, A.V., et al., Polymorphism of uncoupling protein genes in football players: investigation of the functional role, Hum. Physiol., 2016, vol. 42, no. 6, p. 645.CrossRefGoogle Scholar
  10. 10.
    Bondareva, E.A., Parfenteva, O.I., and Son’kin, V.D., “Lean” genotype: obesity or athletic success? Vestn. Mosk. Univ., Ser. 23: Antropol., 2017, no. 3, p. 56.Google Scholar
  11. 11.
    Shapiro, S.S. and Wilk, M.B., An analysis of variance test for normality, Biometrika, 1965, vol. 52, no. 3, p. 591.CrossRefGoogle Scholar
  12. 12.
    Mann, H.B. and Whitney, D.R., On a test of whether one of two random variables is stochastically larger than the other, Ann. Math. Stat., 1947, vol. 18, p. 50.CrossRefGoogle Scholar
  13. 13.
    Kruskal, W.H. and Wallis, W.A., Use of ranks in one-criterion variance analysis, J. Am. Stat. Assoc., 1952, vol. 47, no. 260, p. 583.CrossRefGoogle Scholar
  14. 14.
    Schrauwen, P. and Hesselink, M., UCP2 and UCP3 in muscle controlling body metabolism, J. Exp. Biol., 2002, vol. 205, p. 2275.Google Scholar
  15. 15.
    Donadelli, M., Dando, I., Fiorini, C., and Palmieri, M., UCP2, a mitochondrial protein regulated at multiple levels, Cell Mol. Life Sci., 2014, vol. 71, no. 7, p. 1171.CrossRefGoogle Scholar
  16. 16.
    Ahmetov, I.I., Williams, A.G., Popov, D.V., et al., The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes, Hum. Genet., 2009, vol. 126, p. 751.CrossRefGoogle Scholar
  17. 17.
    Holdys, J., Gronek, P., Kryściak, J., and Stanis-ławsk, D., Genetic variants of uncoupling proteins-2 and -3 in relation to maximal oxygen uptake in different sports, Acta Biochim. Pol., 2013, vol. 60, no. 1, p. 71.Google Scholar
  18. 18.
    Dhamrait, S.S., Williams, A.G., Day, S., et al., Variation in the uncoupling protein 2 and 3 genes and human performance, J. Appl. Physiol., 2012, vol. 112, p. 1122CrossRefGoogle Scholar
  19. 19.
    Perusse, L., Rankinen, T., Hagberg, J.M., et al., Advances in exercise, fitness, and performance genomics in 2012, Med. Sci. Sports Exercise, 2013, vol. 45, p. 824.CrossRefGoogle Scholar
  20. 20.
    Dato, S., Soerensen, M., Lagani, V., et al., Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway, Exp. Gerontol., 2014, vol. 52, p. 23.CrossRefGoogle Scholar
  21. 21.
    Keogh, J., Palmer, B., Taylor, D., and Kilding, E., ACE and UCP2 gene polymorphisms and their association with baseline and exercise-related changes in the functional performance of older adults, Peer. J., 2015, vol. 3, p. 980.CrossRefGoogle Scholar
  22. 22.
    Sessa, F., Chetta, M., Petito, A., et al., Gene polymorphisms and sport attitude in Italian athletes, Gene. Test. Mol. Biomarkers, 2011, vol. 15, p. 285.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • E. A. Bondareva
    • 1
  • O. I. Parfenteva
    • 2
    • 4
  • A. V. Kozlov
    • 2
  • U. S. Zhuravleva
    • 3
  • E. V. Kosyakova
    • 3
  • E. E. Karelina
    • 3
  • E. S. Ketlerova
    • 3
  • V. D. Son’kin
    • 2
    • 4
    Email author
  1. 1.Institute and Museum of Anthropology, Moscow State UniversityMoscowRussia
  2. 2.Moscow Center of Advanced Sports Technologies, Department of Physical Culture and Sports of MoscowMoscowRussia
  3. 3.Department of Physical Education and Sports, RUDN UniversityMoscowRussia
  4. 4.Russian State University of Physical Education, Sports, Youth, and TourismMoscowRussia

Personalised recommendations