Human Physiology

, Volume 43, Issue 7, pp 769–773 | Cite as

Variation of the State of Lower Limb Veins in Cosmonauts during Long-term Missions

  • A. R. Kotovskaya
  • G. A. Fomina
  • A. V. Salnikov


This paper reports changes in the main parameters of lower limb veins in 35 cosmonauts in the course of six-month space missions. Major reduction in the leg volume was shown in all cosmonauts, as well as a significant increase in venous capacitance and compliance. The rate of lower leg vein filling exhibited different trends; it was decreased in the majority of cosmonauts (n = 26, 74%) and increased in the rest (n = 9, 26%). Increases in venous capacitance, compliance, and filling rates may impact orthostatic stability (OS). These changes are among the pathophysiological mechanisms of the OS loss in spaceflight.


space mission microgravity hemodynamics veins pathophysiological mechanisms 


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Copyright information

© Pleiades Publishing, Inc. 2017

Authors and Affiliations

  • A. R. Kotovskaya
    • 1
  • G. A. Fomina
    • 1
  • A. V. Salnikov
    • 1
  1. 1.Institute of Biomedical ProblemsRussian Academy of SciencesMoscowRussia

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