Toll-Like Receptors in Peripheral Blood Cells of Cosmonauts after Long-term Missions on Board the International Space Station
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Studies of Toll-like receptors (TLR) in 20 cosmonauts, members of long-term (124- to 199-day) missions on board the International Space Station showed changes in the relative and absolute counts of peripheral blood monocytes with TLR2, TLR4, and TLR6 on their surface, expression of genes TLR2 and TLR6, as well as genes of molecules involved in the TLR signaling pathway and TLR-related NF-κB-, JNK/p38- and IRF pathways on the day of return to Earth. The observed changes displayed individual variability.
Keywordsimmunity system Toll-like receptors (TLR) space missions
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- 1.Lebedev, K.A. and Ponyakina, I.D., Immunologiya obrazraspoznayushchikh retseptorov (integral’naya immunologiya) (Immunology of Pattern Recognizing Receptors: Integrated Immunology), Moscow: Librokom, 2009.Google Scholar
- 12.O’Neill, L.A., Fitzgerald, K.A., and Bowie, A.G., The Toll-IL1 receptor adaptor family grows to five members, Trends Immunol., 2003, vol. 24, no. 6, pp. 287–290.Google Scholar
- 15.Wendling, U., Paul, L., van der Zee, R., et al., A conserved mycobacterial heat shock protein (HSP) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL10-producing T-cells that cross-react with the mammalian self-HSP70 homologue, J. Immunol., 2000, vol. 164, no. 5, pp. 2711–2717.CrossRefPubMedGoogle Scholar
- 16.Morukov, B.V., Rykova, M.P., Antropova, E.N., et al., The human immune system, in Kosmicheskaya meditsina i biologiya (Space Medicine and Biology), Grigor’ev, A.I. and Uchakov, I.B., Eds., Voronezh: Nauchnaya Kniga, 2013, pp. 449–453.Google Scholar