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Human Physiology

, Volume 42, Issue 2, pp 214–222 | Cite as

Distribution of polymorphic variants of the GSTP1 gene involved in biotransformation of xenobiotics in Tundra Nenets and Nganasans in comparison to Russians

  • R. P. Tiis
  • L. P. Osipova
  • D. V. Lichman
  • L. E. Tabikhanova
  • T. V. Churkina
  • E. N. Voronina
  • M. L. Filipenko
  • S. G. Krivoschekov
Article
  • 20 Downloads

Abstract

The first study on the frequencies of polymorphic variants of the GSTP1 gene encoding glutathione-S-transferase P1 in Tundra Nenets and Nganasan populations was performed. The subject of the study was the single nucleotide polymorphisms rs1695 (Ile105Val substitution in the protein sequence) and rs1138272 (Ala114Val substitution) that had previously been shown to be associated with cancer and other multifactorial diseases. The data for Tundra Nenets of the Yamalo-Nenets autonomous okrug, Nganasans of the Taimyr Peninsula, and Russian residents of the Northern Siberia were compared. The frequencies of the mutant 105Val and 114Val variants were 10.8% and 0.8% in Nganasans, 23.7% and 4.8% in Nenets, and 35.8% and 9.1% in Russian population samples, respectively. The differences within all pairs of populations were significant for each allele. These differences may characterize the population-level susceptibility to cancer and other multifactorial diseases.

Keywords

Nganasans Tundra Nenets Russians populations xenobiotic biotransformation glutathione-S-transferase k]GSTP1 rs1695 rs1138272 Ile105Val Ala114Val 

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Copyright information

© Pleiades Publishing, Inc. 2016

Authors and Affiliations

  • R. P. Tiis
    • 1
  • L. P. Osipova
    • 1
    • 2
  • D. V. Lichman
    • 1
    • 2
  • L. E. Tabikhanova
    • 1
  • T. V. Churkina
    • 1
  • E. N. Voronina
    • 2
    • 3
  • M. L. Filipenko
    • 2
    • 3
  • S. G. Krivoschekov
    • 4
  1. 1.Institute of Cytology and Genetics, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia
  3. 3.Institute of Chemical Biology and Fundamental Medicine, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  4. 4.Institute of Physiology and Fundamental MedicineNovosibirskRussia

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