Human Physiology

, Volume 41, Issue 3, pp 296–303 | Cite as

The effect of single aerobic exercise on the regulation of mitochondrial biogenesis in skeletal muscles of trained men: A time-course study

  • D. V. PopovEmail author
  • E. A. Lysenko
  • T. F. Miller
  • A. V. Bachinin
  • D. V. Perfilov
  • O. L. Vinogradova


The study focused on the effects of duration of a single aerobic exercise session of moderate intensity (60% of {ie296-1}) on the activation of PGC-1α gene expression-regulating signaling kinases and the expression of the genes that regulate mitochondrial biogenesis and play a role in regulating catabolism. Nine athletes ({ie296-2} 59 mL/min/kg) cycled on a ergometer for 30, 60, and 90 min. A exercise-induced increase in PGC-1α gene expression was found to occur without activation of the kinases AMPK, p38 MAPK, and CaMKII. A comparable increase in PGC-1α gene expression was observed after 60- and 90-min exercises, while VEGFA gene expression increased only after 90-min exercise. Even 90-min exercise of the given intensity did not activate the FOXO1-E3 ubiquitin ligase pathway, nor did it increase the expression of catabolism-regulating genes.


exercise skeletal muscle gene expression PGC-1α 


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Copyright information

© Pleiades Publishing, Inc. 2015

Authors and Affiliations

  • D. V. Popov
    • 1
    • 2
    Email author
  • E. A. Lysenko
    • 1
  • T. F. Miller
    • 1
  • A. V. Bachinin
    • 1
  • D. V. Perfilov
    • 1
  • O. L. Vinogradova
    • 1
    • 2
  1. 1.Institute of Biomedical ProblemsRussian Academy of SciencesMoscowRussia
  2. 2.Moscow State UniversityMoscowRussia

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