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Human Physiology

, Volume 41, Issue 3, pp 328–335 | Cite as

Endotoxin is a component in the pathogenesis of chronic viral diseases

  • I. A. Anikhovskaya
  • A. A. Kubatiev
  • G. R. Khasanova
  • M. Yu. YakovlevEmail author
Article

Abstract

The level of endotoxin and indicators of the activity of anti-endotoxin immunity (the concentration of antibodies against Re chemotype glycolipid and enterobacterial common antigen) were determined in the serum of 174 patients with persistent viral infections (with herpes simplex, hepatitis C, and human immunodeficiency viruses). In HIV-infected patients, the presence of markers of the systemic inflammatory response syndrome (interleukin IL-1β) and acquired immunodeficiency (CD4+) was also determined. Persistent viral infections have been found to be accompanied by endotoxin aggression of intestinal origin, which they cause themselves and which can induce the systemic inflammatory response syndrome. In HIV-infected patients, this syndrome is cyclic, the phase of hyperactivity alternating with immunodeficiency. Schematically, this process can be represented as the following sequence of events: HIV-mediated damage to the intestinal barrier-development of endotoxin aggression-induction the of systemic inflammatory response syndrome-immune exhaustion, which is transient and related to the duration of the virus replication cycle, i.e., with the damage to enterocytes. The use of the anti-endotoxin component (a tool for reducing the levels of endotoxin in blood) in the scheme of treatment for persistent viral infections can contribute to successful prevention of complications.

Keywords

lipopolysaccharide endotoxin aggression viral iridocyclitis chronic hepatitis C HIV infection systemic inflammatory response syndrome acquired immunodeficiency syndrome 

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Copyright information

© Pleiades Publishing, Inc. 2015

Authors and Affiliations

  • I. A. Anikhovskaya
    • 1
    • 3
  • A. A. Kubatiev
    • 1
  • G. R. Khasanova
    • 2
  • M. Yu. Yakovlev
    • 1
    • 4
    Email author
  1. 1.Research Institute of General Pathology and PathophysiologyRussian Academy of SciencesMoscowRussia
  2. 2.Kazan State Medical University and Republican Center for AIDS and Infectious Disease Prevention and ControlMinistry of Health of the Republic of TatarstanKazan, TatarstanRussia
  3. 3.Institute of General and Clinical Pathology, Clinical Diagnostic SocietyRussian Academy of Natural SciencesMoscowRussia
  4. 4.Russian State Medical UniversityMoscowRussia

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