Human Physiology

, Volume 39, Issue 7, pp 787–791 | Cite as

Investigation of the evacuation function of the gastrointestinal tract during a five-day dry immersion

  • B. V. Afonin
  • E. A. Sedova
  • N. P. Goncharova
  • A. A. Solovieva
Experimental and Theoretical Studies

Abstract

Six male volunteers for dry immersion (DI) simulating microgravity effects in the human body were subjects in the study on the evacuation function of the gastrointestinal tract (GIT). The investigation was aimed to evaluate liquid food evacuation from the stomach (the 13C-acetate test) and time of chymus orocecal transit (the H2-inulin test). The 13C-acetate test did not reveal changes in stomach evacuation activity after 4 days in DI. The H2-inulin test demonstrated shortening of the chymus’s transit along the small intestine and extension of chymus passage from the oleum to cecum. The subsequent reduction of inulin metabolism in the large intestine suggested inhibited passage of these GIT segments. The results showed that the stability of liquid evacuation from the stomach and acceleration of the chymus’s transit along the small intestine hinder evacuation of the large intestine content, which is the primary cause of the inhibition of the GIT evacuation activity during DI.

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References

  1. 1.
    Afonin, B.V., The state of the digestive system during long spaceflights and hypokinesia, Ros. Zh. Gastroenterol., Gepatol., Koloproktol, 1999, vol. 9,Suppl. 7. p. 5.Google Scholar
  2. 2.
    Afonin, B.V., Noskov, V.B., and Polyakov, V.V., The state of the digestive organs during long spaceflight, Hum. Physiol., 2003, vol. 29, no. 5, p. 561.CrossRefGoogle Scholar
  3. 3.
    Afonin, B.V., Noskov, V.B., Nichiporuk, I.A., et al., The state of organs and vessels of abdominal cavity at simulation of venous plethora in splanchnic basin, Aviakosm. Ekol. Med., 2007, vol. 41, no. 5, p. 24.Google Scholar
  4. 4.
    Afonin, B.V., Goncharova, N.P., and Karamyshev, Yu.A., Functional state of the stomach in long-term antiorthostatic hypokinesia, Aviakosm. Ekol. Med., 2007, vol. 41, no. 6, p. 34.Google Scholar
  5. 5.
    Afonin, B.V., Goncharova, N.P., and Sedova, E.A., Skin electrical activity of the stomach and intestine during long-term antiorthostatic hypokinesia, Hum. Physiol., 2007, vol. 33, no. 6, p. 747.CrossRefGoogle Scholar
  6. 6.
    Afonin, B.V. and Goncharova, N.P., Secretory activity of the stomach at simulation of increased blood content of the venous system of abdominal cavity in an antiorthostatic position, Aviakosm. Ekol. Med., 2009, vol. 43, no. 4, p. 39.Google Scholar
  7. 7.
    Afonin, B.V. and Sedova, E.A., The state of the digestive system at simulation of effects of microgravity in the human body under the conditions of immersion, Aviakosm. Ekol. Med., no. 1, p. 11.Google Scholar
  8. 8.
    Glants, S.A., Biomedical Statistics, New York: McGr aw Hill (1994).Google Scholar
  9. 9.
    Zvenigorodskaya, L.A., Konev, Yu.V., and Efremov, L.I., Evolution of concepts of metabolic syndrome, Eksperim. Klin. Gastroenterol., 2010, no. 7, p. 3.Google Scholar
  10. 10.
    Rapoport, S.I., Shubina, N.A., and Semenova, N.V., 13S-dykhatel’nyi test v praktike gastroenterologa (13S Breathing Test in the Practice of a Gastroenterolist), Moscow, 2007.Google Scholar
  11. 11.
    Rechkalov, A.V., Kuznetsov, A.P., and Kozhevnikov, V.I., Radionuclide study of the evacuation function of the gastrointestinal tract in persons with different levels of daily motor activity, Ros. Zh. Gastroenterol., Gepatol., Koloproktol., 2009, no. 5, p. 23.Google Scholar
  12. 12.
    Smirnov, K.V. and Ugolev, A.M., Kosmicheskaya gastroenterologiya (Space Gastroenterology), Moscow, 1981.Google Scholar
  13. 13.
    Smirnov, K.V., Pishchevarenie i gipokineziya (Digestion and Hypokinesia), Moscow, 1990.Google Scholar
  14. 14.
    Smirnov, K.V., Formation of hypokinetic syndrome of the digestive system under the conditions of microgravity, Fiziol. Zh., 1992, vol. 78, no. 8, p. 93.Google Scholar
  15. 15.
    Smirnov, K.V. and Ugolev, A.M., Digestion and absorption, Kosm. Biol. Med., 1997, vol. 3, Book 1, Chapter 9, p. 357.Google Scholar
  16. 16.
    Tsodikov, G.V., Zyakun, A.M., Isakov, V.A., and Afonin, B.V., Use of isotope mass-spectrometry in gastroenterological practice, in Al’manakh klin. med.: novoe v patogeneze, diagnostike i lechenii zabolevanii zheludochno-kishechnogo trakta, assotsiirovannykh s Helicobacter pylori (Anthology of Clinical Medicine: New in Pathogenesis, Diagnostics, and Treatment of Diseases of the Gastrointestinal Tract Asscociated with Helicopter pylori), 2006, vol. 14, p. 143.Google Scholar
  17. 17.
    Basilisco, G. and Grisicato, R., Bonazzi, P., et al., H2-breath testing for evaluation of oro-caecal transit time, Aliment. Pharmacol. Ther., 2009, vol. 29, p. 23.Google Scholar
  18. 18.
    Capello, G., Malatesta, M.G., Ferry, A., et al., Gastric empting of a solid liquid meal measured with 13C-octanoic acid breath test and real-time ultrasonography a comparative study, Am. J. Gastroenterol., 2000, vol. 95, no. 1, p. 3097.Google Scholar
  19. 19.
    Distefano, M., Certo, M., Colecchia, A., et al., H2-breath tests: methodological audits in adults and children, Blackwell Publishing Ltd Aliment. Pharmacol. Ther., 2009, vol. 29, p. 21.Google Scholar
  20. 20.
    Keller, J., Fliegner-Baia, M., and Layer, P., 13C-gastric empting breath tests physical activity alters normal values of the “European standard” 13C-octanoic acid breath test, Gut, 2002, vol. 51, p. 3.CrossRefGoogle Scholar
  21. 21.
    Keller, J. and Layer, P., Intestinal function tests, Schweiz Rundzch Med. Prax, 2005, vol. 94, no. 37, p. 1433.Google Scholar

Copyright information

© Pleiades Publishing, Inc. 2013

Authors and Affiliations

  • B. V. Afonin
    • 1
  • E. A. Sedova
    • 1
  • N. P. Goncharova
    • 1
  • A. A. Solovieva
    • 1
  1. 1.Institute of Biomedical ProblemsMoscowRussia

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