Human Physiology

, Volume 39, Issue 5, pp 472–479

Prediction of human orthostatic tolerance by changes in arterial and venous hemodynamics in the microgravity environment

  • A. R. Kotovskaya
  • G. A. Fomina
Article
  • 75 Downloads

Abstract

In this article, we intentionally present exclusively the results of our recent studies of arterial and venous hemodynamics as predictors of human orthostatic tolerance during space flight and after the return to Earth. The possibility of in-flight orthostatic tolerance prediction by arterial hemodynamic responses to the lower body negative pressure (LBNP) and venous hemodynamic changes in response to occlusion of the lower extremities is demonstrated. For the first time, three levels of cerebral blood flow deficits during the determination of orthostatic tolerance in the course of the LBNP test performed in microgravity. We offer quantitative arguments for the dependence of the cerebral blood flow deficit on the degree of tolerance of the LBNP test. Patterns of arterial hemodynamics during LBNP were successfully used to diagnose the actual orthostatic tolerance and to follow its trend during flight, which testifies to the possibility of predicting orthostatic tolerance changes in an individual cosmonaut during space flight. Occlusion plethysmography of the legs revealed three levels of response of the most informative venous parameters (capacity, distensibility, and rate of filling) of the lower extremities correlated to the severity of decrease in orthostatic tolerance.

Keywords

microgravity space flight hemodynamics orthostatic tolerance 

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References

  1. 1.
    Grigor’ev, A.I., Kotovskaya, A.R., and Fomina, G.A., Characteristics of functioning of the cardiovascular system of humans in space flight, in Serdechno-sosudistaya patologiya. Sovremennoe sostoyanie problemy (Cardiovascular Disease. The Current State of the Problem), Moscow: Media Medica, 2009.Google Scholar
  2. 2.
    Kotovskaya, A.R. and Fomina, G.A., Characteristics of adaptation and maladaptation of human cardiovascular system under space flight conditions, Hum. Phys., 2010, vol. 36, no. 2, p. 190.CrossRefGoogle Scholar
  3. 3.
    Fomina, G.A., Kotovskaya, A.R., Polyakov, V.V., et al., The influence of microgravity on the central and peripheral hemodynamics of humans according to ultrasound research data, Orbital. Stantsiya MIR, 2002, vol. 2, chap. 8, p. 529.Google Scholar
  4. 4.
    Gazenko, O.G., Man in space, Kosm. Biol., 1984, vol. 18, no. 1, p. 3.Google Scholar
  5. 5.
    Pestov, I.D. and Geratevol, Z.J., Microgravity, in Osnovy kosmicheskoi biologii i meditsiny (Basics of Space Biology and Medicine), Moscow, 1975, vol. 2, no. 1, p. 324.Google Scholar
  6. 6.
    Gauer, O.H. and Henry, J.P., Circulatory basis of fluid volume control, Physiol. Rev., 1963, vol. 43, p. 423.PubMedGoogle Scholar
  7. 7.
    Gazenko, O.G., Results and prospects of physiological studies in space flights, Vestn. Akad. Med. Nauk, 1984, no. 4, p. 7.Google Scholar
  8. 8.
    Gazenko, O.G., Grigor’ev, A.I., and Egorov, A.D., Human body responses in space flight, in Fiziologicheskie problemy nevesomosti (The Physiological Problems of Microgravity), Gazenko, O.G. and Kas’yan, I.I., Eds., Moscow, 1990, p. 15.Google Scholar
  9. 9.
    Grigor’ev, A.I. and Egorov, A.D., Long-term space missions, in Kosmicheskaya biologiya i meditsina. Sovmestnoe rossiisko-amerikanskoe izdanie v 5 tomakh (Space Biology and Medicine. Joint Russian-American Edition in 5 Volumes), Gazenko, O.G., Grigor’ev, A.I., Nikogosyan, A.E., and Molera, S.R., Eds., Moscow: Nauka, 1997, vol. III, no. 2, p. 368.Google Scholar
  10. 10.
    Grigor’ev, A.I. and Egorov, A.D., Phenomenology and mechanisms of changes in the basic functions of the human body in microgravity, Kosm. Biol. Aviakosm. Med., 1988, vol. 22, no. 12, p. 4.PubMedGoogle Scholar
  11. 11.
    Grigor’ev, A.I. and Egorov, A.D., Regulation of the human cardiovascular system in microgravity, Vestn. Ross. Akad. Med. Nauk, 2002, no. 6, p. 52.Google Scholar
  12. 12.
    Egorov, A.D., Itsekhovskii, O.G., Alferova, I.V., et al., Studies of the cardiovascular system during long-term space flights, in Fiziologicheskie problemy nevesomosti (The Physiological Problems of Microgravity), Gazenko, O.G. and Kas’yan, I.I., Eds., Moscow: Meditsina, 1990, p. 70.Google Scholar
  13. 13.
    Bungo, H.W. and Charles, J.B., The human cardiovascular system in the absence of gravity, IAF, 1985, vol. 135.Google Scholar
  14. 14.
    Arbeille, Ph., Pavy le Traon, A., Fomina, G., et al., Femoral artery flow response to LBNP, as an indicator of orthostatic tolerance. Application to long term head down tilt and spaceflight, Aviat. Space Environ. Med., 1995, vol. 66, p. 131.PubMedGoogle Scholar
  15. 15.
    Arbeille, Ph., Fomina, G., Alferova, I., et al., Cerebral and femoral flow response to lbnp during 6 month mirspaceflights, Acta Astron., 1996, vol. 36, p. 6.Google Scholar
  16. 16.
    Suvorov, P.M., Karlov, V.N., and Sidorova, K.A., Spetsial’naya funktsional’naya diagnostika vrachebno-letnoi ekspertizy (Special Functional Diagnostics of Medical and Flight Examination), Moscow: Slovo, 1996.Google Scholar
  17. 17.
    Shik, L.L., Sergeeva, K.A., and Moiseev, V.A., The study of the causes of orthostatic intolerance, in Problemy kosmicheskoi biologii (Problems of Space Biology), Moscow: Nauka, 1975, vol. 31, p. 157.PubMedGoogle Scholar
  18. 18.
    Buckey, J.C., Lane, L.D., Levine, B.D., et al., Orthostatic intolerance after spaceflight, J. Appl. Physiol., 1996, vol. 81, no. 1, p. 7.PubMedGoogle Scholar
  19. 19.
    Tyberg, J.V. and Hamilton, V.R., Orthostatic hypotension and the role of changes in venous capacitance, Med. Sci. Sport Exerc., 1996, vol. 28, p. 29.CrossRefGoogle Scholar
  20. 20.
    Convertino, V.A., Mechanisms underlying orthostatic intolerance, Jpn. J. Pathophysiol., 2000, vol. 9, p. 25.Google Scholar
  21. 21.
    Egorov, A.D., Mechanisms of orthostatic tolerance in long-term space flights, Aviakosm. Ekol. Med., 2001, vol. 35, no. 6, p. 3.Google Scholar
  22. 22.
    Fomina, G.A. and Kotovskaya, A.R., Changes in venous hemodynamics in human long-term space missions, Aviakosm. Ekol. Med., 2005, vol. 39, no. 4, p. 25.Google Scholar
  23. 23.
    Khayutin, V.M., Shenderov, S.M, Zakharov, A.G., and Rogoza, A.N., Orthostatic instability of circulation: the role of detraining of resistive vessels, Kosm. Biol. Avikosmich. Med., 1984, vol. 18, no. 4, p. 4.Google Scholar
  24. 24.
    Fomina, G.A., Kotovskaya, A.R., Pochuev, V.I., and Zhernavkov, A.F., Changes in hemodynamic mechanisms ensuring human orthostatic tolerance during long-term space missions, Aviakosm. Ekol. Med., 2005, vol. 39, no. 6, p. 9.Google Scholar

Copyright information

© Pleiades Publishing, Inc. 2013

Authors and Affiliations

  • A. R. Kotovskaya
    • 1
  • G. A. Fomina
    • 1
  1. 1.Institute of Biomedical Problems (IBMP)Russian Academy of SciencesMoscowRussia

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