Association of muscle-specific creatine kinase (CKMM) gene polymorphism with physical performance of athletes
- 232 Downloads
The distribution of allele and genotype frequencies of the muscle-specific creatine kinase (CKMM) gene A/G polymorphism in athletes (n = 384) and control subjects (n = 1116) was investigated, and the interrelation between genotypes and aerobic capacity in boat race rowers (n = 85) was revealed. Genotyping was performed using restriction fragment length polymorphism (RFLP) analysis. The aerobic capacity (the maximum oxygen uptake (VO2max) and the maximum power production capacity (W max)) were determined using an incremental test until exhaustion with a rowing ergometer. The CKMM A allele and AA genotype frequencies were significantly higher in endurance athletes (n = 176) than in control subjects (A allele: 78.7% vs. 65.4%; p < 0.0001; AA genotype: 59.7% vs. 44.2%; p = 0.0003). On the other hand, the GG genotype was more prevalent in weightlifters (n = 74) compared to control subjects (31.1% vs. 13.4%; p = 0.0001). Furthermore, the CKMM AA genotype was associated with high values of VO2max (AA, 58.98 (3.44) ml/(kg min); GA, 56.99 (4.36) ml/(kg min); GG, 52.87 (4.32) ml/(kg min); p = 0.0097). Thus, the CKMM gene A/G polymorphism is associated with the physical performance of athletes.
KeywordsCKMM polymorphism physical performance
Unable to display preview. Download preview PDF.
- 2.Wallimann, T. and Eppenberger, H.J., Cell and Muscle Motility, Shay, J.W., Ed., New York: Plenum, 1985.Google Scholar
- 13.Wilson, I.A., Brindle, K.M., and Fulton, A.M., Differential Localization of the mRNA of the M and B Isoforms of Creatine Kinase in Myoblasts, J. Biochem., 1995, vol. 308, p. 599.Google Scholar
- 18.Rivera, M.A., Perusse, L., Simoneau, J.A., et al., Linkage between a Muscle-Specific CK Gene Marker and VO2max in the Heritage Family Study, Med. Sci. Sports Exerc., 1997, vol. 31, p. 698.Google Scholar
- 23.Bolla, M.K., Haddad, L., Humphries, S.E., et al., A Method of Determination of Hundreds of APOE Genotypes Using Highly Simplified, Optimized Protocols and Restriction Digestion Analysis by Microtitre Array Diagonal Gel Electrophoresis (MADGE), Clin. Chem., 1995, vol. 41, p. 1599.PubMedGoogle Scholar
- 25.Bouchard, C., Sarzynski, M.A., Rice, T.K., et al., Genomic Predictors of Maximal Oxygen Uptake Response to Standardized Exercise Training Programs, J. Appl. Physiol., 2010.Google Scholar