Human Physiology

, Volume 38, Issue 1, pp 89–93 | Cite as

Association of muscle-specific creatine kinase (CKMM) gene polymorphism with physical performance of athletes

  • O. N. Fedotovskaya
  • D. V. Popov
  • O. L. Vinogradova
  • I. I. Akhmetov


The distribution of allele and genotype frequencies of the muscle-specific creatine kinase (CKMM) gene A/G polymorphism in athletes (n = 384) and control subjects (n = 1116) was investigated, and the interrelation between genotypes and aerobic capacity in boat race rowers (n = 85) was revealed. Genotyping was performed using restriction fragment length polymorphism (RFLP) analysis. The aerobic capacity (the maximum oxygen uptake (VO2max) and the maximum power production capacity (W max)) were determined using an incremental test until exhaustion with a rowing ergometer. The CKMM A allele and AA genotype frequencies were significantly higher in endurance athletes (n = 176) than in control subjects (A allele: 78.7% vs. 65.4%; p < 0.0001; AA genotype: 59.7% vs. 44.2%; p = 0.0003). On the other hand, the GG genotype was more prevalent in weightlifters (n = 74) compared to control subjects (31.1% vs. 13.4%; p = 0.0001). Furthermore, the CKMM AA genotype was associated with high values of VO2max (AA, 58.98 (3.44) ml/(kg min); GA, 56.99 (4.36) ml/(kg min); GG, 52.87 (4.32) ml/(kg min); p = 0.0097). Thus, the CKMM gene A/G polymorphism is associated with the physical performance of athletes.


CKMM polymorphism physical performance 


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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • O. N. Fedotovskaya
    • 1
  • D. V. Popov
    • 2
  • O. L. Vinogradova
    • 2
  • I. I. Akhmetov
    • 1
    • 2
    • 3
  1. 1.St. Petersburg Research Institute of Physical CultureSt. PetersburgRussia
  2. 2.Institute of Biomedical ProblemsRussian Academy of SciencesMoscowRussia
  3. 3.Kazan State Medical UniversityKazanRepublic of Tatarstan, Russia

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