Human Physiology

, 37:217

Cardiovascular effects of the nerve growth factor: An analytical review. Part I: NGF-mediated intracellular signaling pathways

  • S. A. Kryzhanovskii
  • M. B. Vititnova


Traditionally, the nerve growth factor (NGF) is considered to be a chemoattractant participating in the regulation of cell proliferation, differentiation, and neuron myelination. However, the currently available data suggest that the physiological role of NGF in the body is much wider. The features of NGF influence on the functional activity of the cardiovascular system, signaling pathways by which activated NGF TrkA and p75ntr receptors regulate the functional state of endothelial and vascular smooth muscle cells and cardiomyocytes are discussed. In addition, the theoretical prospects of agonists and antagonists of TrkA and p75ntr receptors for the treatment of heart and vascular disorders are considered.


NGF TrkA p75ntr signal pathways vascular endothelial cells vascular smooth muscle cells cardiomyocytes 


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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • S. A. Kryzhanovskii
    • 1
  • M. B. Vititnova
    • 1
  1. 1.Zakusov Institute of PharmacologyRussian Academy of SciencesMoscowRussia

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