Correction of venous congestion in abdominal organs under antiorthostatic conditions
- 29 Downloads
The effect of a diuretic on the ultrasound pattern of venous congestion in abdominal organs in a healthy subject staying in an antiorthostatic position (AOP, 15°) for 12 h was studied. After furosemide administration, the circulating plasma volume (CPV), total water content of the body, and extracellular fluid volume decreased more than without the treatment. Overall hypohydration of the body prevented the dilation of hepatic veins typical of an AOP while not affecting noticeably the venous congestion in the portal vein system. In addition, the administration of the diuretic prevented the activation of bile secretion and an increased gastric juice secretion under antiorthostatic conditions. Thus, it was demonstrated that pharmacological hypohydration, by decreasing the CPV and the blood pressure in the inferior vena cava, unloads hepatic veins and prevents enhanced secretion in organs of the digestive system under the conditions of gravitational redistribution of body fluids.
Unable to display preview. Download preview PDF.
- 1.Smirnov, K.V., Pishchevarenie i gipokineziya (Digestion and Hypokinesia), Moscow: Meditsina, 1990.Google Scholar
- 2.Afonin, B.V., The State of the Digestive System during Long-term Spaceflights and in Hypokinesia, Ross. Zh. Gastroenterol. Gepatol. Koloproktol., 1999, vol. 9, suppl. 7, p. 5.Google Scholar
- 3.At’kov, O.Yu. and Bednenko, V.S., Gipokinesia, nevesomost’: Klinicheskie i fiziologicheskie aspekty (Hypokinesia and Microgravity: Clinical and Physiological Aspects), Moscow: Nauka, 1989.Google Scholar
- 4.Afonin, B.V., Noskov, V.B., and Polyakov, V.V., The State of the Digestive Organs during Long Spaceflight, Fiziol. Chel., 2003, vol. 29, no. 5, p. 53 [Hum. Physiol. (Engl. Transl.), 2003, vol. 29, no. 5, p. 561].Google Scholar
- 5.Chelovek v kosmicheskom polete (Humans in Spaceflight), Antipov, V.N., Grigor’ev, A.I., and Khantun, L., Eds., Moscow: Nauka, 1997, vol. 3, book 1.Google Scholar
- 6.Noskov, V.B., Correction of the Human Body Hydration Level at Different Stages of Spaceflight, Aviakosm. Ekol. Med., 2003, vol. 37, no. 2, p. 19.Google Scholar
- 7.Bagrov, Ya.Yu., Vodno-solevoi gomeostaz pri nedostatochnosti krovoobrashcheniya (Water-Salt Homeostasis in Circulatory Failure), Leningrad: Nauka, 1984.Google Scholar
- 9.Noskov, V.B., Pharmacological Hypohydration as Means to Increase Human Working Capacity at Early Stages of Spaceflight, Aviakosm. Ekol. Med., 1994, vol. 28, no. 4, p. 9.Google Scholar
- 11.Dergachev, A.I., Ul’trazvukovaya diagnostika zabolevanii vnutrennikh organov (Ultrasound Diagnosis of Internal Diseases), Moscow: Univ. Druzhby Narodov, 1995.Google Scholar
- 13.Glantz, S.A., Primer of Biostatistics, New York: McGraw-Hill, 2002, 5th edition.Google Scholar