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Pulsed cyclic device for liquid countercurrent chromatography

  • A. E. Kostanyan
  • A. A. Voshkin
  • N. V. Kodin
Chemical Engineering Science

Abstract

A new apparatus for the chromatographic separation of liquid mixtures is investigated. The apparatus contains a number of vertical columns connected in a serpentine shape and consisting of cells placed on top of each other. The cells in the columns are separated by perforated septa. A special dosing unit is used to provide a discrete (cyclic) mobile-phase feed [flow?] into the apparatus and a pulsed cyclic mode of phase contact in column cells. Studies on a single column and on an apparatus consisting of four columns have been performed to assess the efficiency of the pulsed cyclic device. The results of experimental investigations have confirmed the potential of the newly developed topic in the area of liquid mixture separation processes.

Keywords

liquid chromatography pulsed mixing cyclic processes 

References

  1. 1.
    Sutherland, I., Hewitson, P., and Ignatova, S., Scale-Up of Counter-Current Chromatography: Demonstration of Predictable Isocratic and Quasi-Continuous Operating Modes from the Test Tube to Pilot/Process Scale, J. Chromatogr. A, 2009, vol. 1216, no. 50, p. 8787.CrossRefGoogle Scholar
  2. 2.
    Sutherland, I., Hewitson, P., and Ignatova, S., New 18-1 Process-Scale Counter-Current Chromatography Centrifuge, J. Chromatogr. A, 2009, vol. 1216, no. 19, p. 4201.CrossRefGoogle Scholar
  3. 3.
    Ito, Y., Origin and Evolution of the Coil Planet Centrifuge, Separ. Purif. Rev., 2005, vol. 34, p. 131.CrossRefGoogle Scholar
  4. 4.
    Countercurrent Chromatography, Chromatographic Science Series, vol. 82, Menet, J.M. and Thiebaut, D., Eds., New York: Marcel Dekker, 1999.Google Scholar
  5. 5.
    High-Speed Countercurrent Chromatography, Ito, Y. and Conway, W.D., Eds. New York: Wiley, 1996.Google Scholar
  6. 6.
    Conway, W.D., Countercurrent Chromatography: Apparatus, Theory and Applications, New York: VCH, 1990.Google Scholar
  7. 7.
    Maryutina, T.A., Fedotov, P.S., and Spivakov, B.Ya., Application of Countercurrent Chromatography to Preconcentration and Separation of Inorganic Sub-stances: Two-Phase Liquid Systems, J. Anal. Chem., 1997,vol. 52, no. 12, p. 1140.Google Scholar
  8. 8.
    Fedotov, P.S., Maryutina, T.A., Pichugin, A.A., and Spivakov, B.Ya., Effect of the Kinetic Properties of the Extraction Systems on the Separation of Some Elements by Liquid Chromatography with a Free Stationary Phase, Zh. Neorg. Khim., 1993, vol. 38, no. 11, p. 1878.Google Scholar
  9. 9.
    Kostanyan, A.E., Description of Liquid-Liquid Chromatography Processes with a Free Stationary Phase, Khim. Tekhnol., 2004, no. 8, pp. 39.Google Scholar
  10. 10.
    Kostanyan, A.E., General Regularities of Liquid Chromatography and Countercurrent Extraction, Theor. Found. Chem. Eng., 2006, vol. 40, no. 6, p. 587.CrossRefGoogle Scholar
  11. 11.
    Kostanyan, A., Maryutina, T.A., Spivakov, B.Ya., and Sutherland, I.A., Countercurrent Chromatographic Separation: A Hydrodynamic Approach Developed for Extraction Columns, J. Chromatogr. A, 2004, vol. 1040, p. 63.CrossRefGoogle Scholar
  12. 12.
    Kostanyan A.E. Modelling Countercurrent Chromatography: a Chemical Engineering Perspective, J. Chromatogr., A, 2002, vol. 973, p. 39.CrossRefGoogle Scholar
  13. 13.
    Kostanyan, A.E., Voshkin, A.A., and Pyatovskii, P.A., RF Patent 2342970 Byull. Izobret., 2009, no. 1.Google Scholar
  14. 14.
    Kostanyan, A.E. and Voshkin, A.A., RF Patent 2342971 Byull. Izobret., 2009, no. 1.Google Scholar
  15. 15.
    Kostanyan, A.E., Analysis of Cyclic Column Chromatography, Theor. Found. Chem. Eng., 2008, vol. 42, no. 5, p. 524.CrossRefGoogle Scholar
  16. 16.
    Kostanyan, à.-Cycle Counter-Current Chromatography, J. Chromatogr. A, 2008, vol. 1211, p. 55.CrossRefGoogle Scholar
  17. 17.
    Kostanyan, À. Byull. Izobret., 2007, no. 23.Google Scholar
  18. 18.
    Kostanyan, A.E. and Voshkin, A.A., Pulsed Cyclic Liquid-Liquid Chromatography, Khim. Tekhnol., 2008, no. 11, p. 594.Google Scholar
  19. 19.
    Kostanyan, A.E. and Voshkin, A.A., Support-Free Pulsed Liquid-Liquid Chromatography, J. Chromatogr. A, 2009, vol. 1216, p. 7761.CrossRefGoogle Scholar
  20. 20.
    Kostanyan, A.E., Belova, V.V., and Kholkin, A.I., Modelling Counter-Current Chromatography and Dual Counter-Current Chromatography Using Longitudinal Mixing Cell and Eluting Counter-Current Distribution Models, J. Chromatogr. A, 2007, vol. 1151, nos. 1–2, p. 142.CrossRefGoogle Scholar
  21. 21.
    Kostanyan, A.E. and Voshkin, A.A., Analysis of New Counter-Current Chromatography Operating Modes, J. Chromatogr. A, 2007, vol. 1151, nos. 1–2, p. 126.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • A. E. Kostanyan
    • 1
  • A. A. Voshkin
    • 1
  • N. V. Kodin
    • 1
  1. 1.Kurnakov Institute of General and Inorganic ChemistryRussian Academy of SciencesMoscowRussia

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