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Russian Journal of Physical Chemistry A

, Volume 93, Issue 13, pp 2681–2686 | Cite as

Aqueous Solubility Enhancement and Thermodynamic Aggregation Behavior of Resveratrol Using an Eco-Friendly Hydrotropic Phenomenon

  • Vasanth Kumar Elakiyaasokan
  • Gayathri Kalyanaraman
  • Nagendra Gandhi NagarajanEmail author
PHYSICAL CHEMISTRY OF SOLUTIONS

Abstract

Resveratrol, a stilbenoid polyphenol compound found in the skin and seeds of black grapes, which is supposed to have biological activity as an anti-inflammatory, anti-tumor, and anti-aging agent. Low oral bioavailability of resveratrol is determined by its low solubility in water. To overcome this, a biocompatible solubilization method is used to intensify the solubility of resveratrol. Hydrotropes (solubilizing agents) such as sodium caprylate, and sodium benzoate under a wide range of concentrations (0‒3 mol/L) and temperature (303–333 K) were used to study the aqueous solubility of resveratrol. It is observed that the solubility of resveratrol is enhanced by 16 times in the presence of sodium caprylate as hydrotrope. Thermodynamic properties like entropy, Gibbs free energy, and enthalpy were determined, and the solubilization process was found to be entropy-driven.

Keywords:

resveratrol hydrotrope solubility thermodynamic aggregation behavior 

Notes

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

REFERENCES

  1. 1.
    K. V. Pandey and S. I. Rizvi, Oxid. Med. Cell. Longev. 2, 270 (2009).CrossRefGoogle Scholar
  2. 2.
    M. Jang, L. Cai, G. O. Udeani, K. V. Slowing, C. F. Thomas, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, R. G. Mehta, R. C. Moon, and J. M. Pezzuto, Science (Washington, DC, U. S.) 275, 218 (1997).CrossRefGoogle Scholar
  3. 3.
    K. P. Bhat and J. M. Pezzuto, Ann. N. Y. Acad. Sci. 957, 210 (2002).CrossRefGoogle Scholar
  4. 4.
    S. Pervaiz, FASEB J. 17, 1975 (2003).CrossRefGoogle Scholar
  5. 5.
    M. Subhendu, I. D. Jocelyn, and K. D. Dipak, Dose Response 8, 478 (2010).Google Scholar
  6. 6.
    J. A. Baur and D. A. Sinclair, Nat. Rev. Drug. Discov. 5, 493 (2006).CrossRefGoogle Scholar
  7. 7.
    R. Vidavalur, H. Otani, P. K. Singal, and N. Maulik, Exp. Clin. Cardiol. 11, 217 (2006).PubMedPubMedCentralGoogle Scholar
  8. 8.
    G. L. Amidon, H. Lennernas, and V. P. Shah, Pharm. Res. 12, 413 (1995).CrossRefGoogle Scholar
  9. 9.
    P. Khadka, J. Ro, H. Kim, I. Kim, J. T. Kim, H. Kim, J. M. Cho, G. Yun, and J. Lee, Asian J. Pharm. Sci. 9, 304 (2014).Google Scholar
  10. 10.
    T. Walle, F. Hsieh, M. H. DeLegge, J. E. Oatis, Jr., and U. K. Walle, Drug. Metab. Dispos. 32, 1377 (2004).CrossRefGoogle Scholar
  11. 11.
    L. Almeida, M. Vaz-da-Silva, and A. Falcao, Mol. Nutr. Food Res. 53 (1), S7 (2009).CrossRefGoogle Scholar
  12. 12.
    D. J. Boocock, K. R. Patel, and G. E. S. Faust, J. Chromatogr. B 848, 182 (2007).CrossRefGoogle Scholar
  13. 13.
    C. Neuberg, Biochem. Z. 76, 107 (1916).Google Scholar
  14. 14.
    N. Nagendra Gandhi and M. Dharmendira Kumar, Bioprocess Eng. 449, 116 (2000).Google Scholar
  15. 15.
    N. Nagendra Gandhi and N. Meyyappan, J. Chem. Eng. Data 49, 1290 (2004).CrossRefGoogle Scholar
  16. 16.
    N. Nagendra Gandhi and N. Meyyappan, J. Chem. Eng. Data 50, 796 (2005).CrossRefGoogle Scholar
  17. 17.
    X. P. Zhang, Y. Le, J. X. Wang, H. Zhao, and J. F. Chen, LWT-Food Sci. Technol. 50, 622 (2013).CrossRefGoogle Scholar
  18. 18.
    D. Balasubramanian, V. Srinivas, V. G. Gaikar, and M. M. Sharma, J. Phys. Chem. 93, 3865 (1989).CrossRefGoogle Scholar
  19. 19.
    D. Gnana Prakash, S. Thenesh Kumar, and N. Nagendra Gandhi, J. Appl. Sci. 9, 2975 (2009).CrossRefGoogle Scholar
  20. 20.
    S. Ozgova, J. Hermanek, and I. Gut, Biochem. Pharmacol. 66, 1127 (2003).CrossRefGoogle Scholar
  21. 21.
    P. V. Pathak and V. G. Gaikar, J. Chem. Eng. Data 38, 217 (1992).Google Scholar
  22. 22.
    M. Desai and J. K. Parikh, World Acad. Sci. Eng. Technol. 57, 227 (2009).Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • Vasanth Kumar Elakiyaasokan
    • 1
  • Gayathri Kalyanaraman
    • 1
  • Nagendra Gandhi Nagarajan
    • 1
    Email author
  1. 1.Department of Chemical Engineering, A.C. Tech Campus, Anna UniversityChennaiIndia

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