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Molecular Biology

, Volume 53, Issue 4, pp 475–483 | Cite as

Molecular Mechanisms of Non-Inherited Antibiotic Tolerance in Bacteria and Archaea

  • T. M. KhlebodarovaEmail author
  • V. A. Likhoshvai
REVIEWS
  • 11 Downloads

Abstract—

The phenomenon of bacterial persistence, also known as non-inherited antibiotic tolerance in a part of bacterial populations, was described more than 70 years ago. This type of tolerance contributes to the chronization of infectious diseases, including tuberculosis. Currently, the emergence of persistent cells in bacterial populations is associated with the functioning of some stress-induced molecular triggers, including toxin–antitoxin systems. In the presented review, genetic and metabolic peculiarities of persistent cells are considered and the mechanisms of their occurrence are discussed. The hypothesis of the origin of persister cells based on bistability, arising due to the non-linear properties of a coupled transcription–translation system, was proposed. Within this hypothesis, the phenomenon of the bacterial persistence of modern cells is considered as a result of the genetic fixation of the phenotypic multiplicity that emerged in primitive cells in the process of neutrally coupled co-evolution (genetic drift of multiple neutrally coupled mutations). Our hypothesis explains the properties of persister cells, as well as their origin and “ineradicable” nature.

Keywords:

molecular trigger cell cycle phenotypic multiplicity bacterial persistence neutrally coupled co-evolution modeling 

Notes

FUNDING

This work was supported by the Program of Fundamental Studies of the Siberian Branch, Russian Academy of Sciences (project no. 0324-2019-0040).

COMPLIANCE WITH ETHICAL STANDARDS

Conflict of interest. The authors declare that they have no conflict of interest.

Statement of the welfare of animals. This article does not contain any studies involving animals or human participants performed by any of the authors.

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© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  1. 1.Institute of Cytology and Genetics, Siberian Branch, Russian Academy of SciencesNovosibirskRussia

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